| Objective:Cancerous inhibitor of protein phosphatase 2A(CIP2A)is recognized as an oncoprotein and may be a prognostic biomarker in various solid tumors.Yet,the results remained not comprehensive.Here we carried out a meta-analysis of published studies to assess the prognostic significance of CIP2A in solid tumors.Methods:All eligible studies were identified by searching PubMed,Embase and Web of Science database updated on 15 Jan 2017.Data about overall survival(OS)and disease-free survival(DFS)were extracted.The Newcastle-Ottawa Scale was used to assess the quality of evidence.Statistical analysis was carried out by Stata14.0.Results:A total of 4457 patients in 21 studies were included,and we verified that CIP2A over-expression was significantly related with poor OS(pooled HR=1.740,95%CI=1.527-1.983,P<0.001)and short DFS(pooled HR =1.808,95%CI=1.591-2.055,P<0.001)in solid tumors.Additionally,subgroup analysis suggested that the trend of a poor OS with an increased CIP2A expression was present in East-Asian and European patients,as well as in lung cancer and colorectal cancer.Conclusion:CIP2A over-expression was associated with poor survival in human solid tumors and might be a predictive factor of poor prognosis. |
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