The General Situation Of Ovarian Reserve Dysfunction Research And Professor Liu Yanfeng's Clinical Observation On The Treatment Of Kidney Deficiency And Liver Stagnation DOR

Objective:In recent years,with the social changes,the age of marriage and the age of actual childbirth are aging,and their physical capabilities have been deviated.On the other hand,assisted reproductive technology(ART)has developed rapidly and some modes of infertility have been proposed.However,it is indispensable to use ART with one's own egg and the ovary has a follicle which will develop healthily.Therefore,predicting ovarian reserve function has become an important link in the implementation of ART,Western medicine has therapeutic methods such as supplemental hormones,but the effectiveness of improving ART success rate is limited.Over the past few years,ART has been popularized in China to a certain extent,especially couples who use in vitro fertilization-embryo transfer(IVF-ET).Prof.Liu Yanfeng use Chinese medicine to treat patients with ovarian reserve deprivation(DOR)or intervene in patients with repeated failure of IVF-ET,advanced high-risk patients,and other senior high-risk patients before using IVF-ET,increase the pregnancy rate and the fetal rate.This study used Professor Liu Yanfeng's experience to observe the changes of menstruation,clinical symptoms and serum hormone levels before and after treatment in patients with DOR of kidney deficiency and liver stagnation,and to explore the experience and clinical efficacy.Methods:This study selected July 2017 to February 2018 to attend the outpatient department of Professor Liu Yanfeng of Department of Gynecology,Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine.According to TCM syndrome differentiation type,there were 20 cases of DOR patients diagnosed as having kidney deficiency and liver depression.Experienced drugs are mainly composed of:Ligustrum lucidum,Gardenia,Loranthaceae,Sichuan off,Huang Jing,Yuzhu,Salvia,turmeric,Chinese angelica,Millettia,etc,warm decoction twice a day(formulation granules:one pack twice a day dissolve warm water),half an hour after breakfast and dinner,taking two consecutive menstrual cycles.The menstrual scores,clinical symptoms,serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)levels were observed before and after treatment.Results:1.Clinical total curative effect:After treatment,10 patients were markedly effective,accounting for 50.0%;9 were effective,accounting for 45.0%;1 was ineffective,accounting for 5.0%.The total effective rate was 95.0%.2.Menstrual score:The patients' menstrual cycle,menstrual period,volume,color,meridian,and blood clot scores all decreased before treatment,and the difference was statistically significant(P<0.01).3.Menstrual symptoms score:The menstrual symptoms(menstrual pain in menstrual period,low back pain in menstrual period,lumbar and abdominal cold in menstrual period,diarrhea in menstrual period,breast tenderness in menstrual period)of the study subjects were all decreased before treatment,and the difference was statistically significant(P<0.05).4.Clinical symptom efficacy score:The clinical symptoms of the study subjects(waist and knee pain,flank pain,impatience,irritability,emotional decline,dizziness,tinnitus,loss of libido,and premenstrual breast tenderness)were reduced before treatment the difference was statistically significant(P<0.05).5.Hormone levels:The FSH,LH,and E2 levels of patients in the study group were improved compared with those before treatment,and the levels of FSH and LH were decreased,and E2 levels were increased.The difference was statistically significant(P<0.05).Conclusion:Prof.Liu Yanfeng's experience has good clinical efficacy on patients with hypofunction of ovarian reserve due to kidney deficiency and liver depression syndrome.It can improve the menstrual situation,menstrual symptoms,clinical symptoms,regulate the endocrine hypothalamus-pituitary-ovarian axis,and reduce the levels of FSH and LH,increase E2 level.