| Objective:Headache is not only an independent disease,but also a manifestation of many acute and chronic diseases.Headache has a high incidence in contemporary society,which seriously affects people's quality of life.Recurrent headache also brings great distress to patients.The western medicine in the treatment of headache is just a temporary problem.Moreover,after taking the side effects and drug resistance have become increasingly prominent.In recent years,Chinese medicine treatment of headache in the highlights of their own unique advantages,and the overall concept of TCM treatment of cleverly combined disease and syndrome of headache,bring great help to the treatment and prognosis of patients.In order to evaluate the curative effect of traditional Chinese medicine in the treatment of headache more objectively,scientifically and quantitatively,and further improve the clinical therapeutic effect evaluation system,so as to better guide the clinical diagnosis and treatment.Therefore,the purpose of this study was to explore the correlation between the biomarkers and clinical efficacy evaluation of headache.Methods:The correlation between the biomarkers and the headache of clinical evaluation,included 24 cases of headache of anger-scrambling syndrome patients and 24 cases of normal group as the object of study,patients were randomly divided into experimental group and control group,the experimental group was given Annao pill,the control group was given Quantianma capsule,detecting serum levels of ?-EP and 5-HT on the day of admission and medication for 14 days.At the same time,using Headache of anger-scrambling syndrome quantitative evaluation table to assess the degree of headache syndromes in patients on the day of admission,medication for 7 days,medication for 14 days,28 days after treatment,patients were asked to record the pain diary card including visual analog scale to assess the severity of headache and seizure,Social Functioning-36 Scale were collected on the day of admission,28 days after treatment as a short-term outcome evaluation.The biomarkers ?-EP,5-HT of 24 normal subjects was collected at the day when they be included.Results:?Correlation between serum ?-EP,5-HT and headache of anger-scrambling syndrome:The result show significant differences in serum?-EP between healthy people and the patients on the day of admission(P=0.028<0.05)and medication for 14 days(P=0.001<0.05).Receiver operator characteristic curves(ROC)analysis show that ?-EP exhibited certain diagnostic accuracy at the two time point with an AUC of 0.695,0.783,respectively,and sensitivity of 65.00%,specificity of 75.00%.The cut-off values of serum ?-EP level for the diagnosis of anger-scrambling syndrome at the two time points were 1.89pg/ml,1.93pg/ml respectively.The result show no statistically difference in serum5-HT between healthy people and the patients on the day of admission(P=0.220>0.05)and medication for 14 days(P=0.259>0.05).Further analysis of the experimental group,the control group of 5-HT serum levels in the day of admission and 14 days of medication group differences,there was no statistically significant difference in the test group(P=0.943>0.05)and control group(P=0.919>0.05).Receiver operator characteristic curves(ROC)analysis show that 5-HT exhibited certain diagnostic accuracy at the two time point with an AUC of 0.585,0.555,respectively,and sensitivity of 50.00%,specificity of 83.30%.The cut-off values of serum 5-HT level for the diagnosis of anger-scrambling syndrome at the two time points were 0.96pg/m,0.89pg/mll respectively.?Correlation between biomarkers 1?-EP,5-HT levels and treatment efficacy evaluation of headache patients:correlation analysis between changes of on the day of admission and medication for 14 days serum ?-EP,5-HT levels and headache situation,anger-scrambling syndrome scores show that:in the test group,the serum ?-EP level was not significantly associated with headache days(r=-0.021,P=0.937>0.05),headache frequency(r=-0.134,P=0.620>0.05),anger-scrambling syndrome scores(r=-0.016,P=0.953>0.05);the serum 5-HT level was not significantly associated with headache days(r=0.309,P=0.185>0.05),headache frequency(r=0.303,P=0.193>0.05),anger-scrambling syndrome scores(r=0.177,P=0.511>0.05).Conclusions:Serum ?-EP levels have some diagnostic value for headache of anger-scrambling syndrome.The serum ?-EP,5-HT levels did not show a significant correlation with efficacy evaluation of headache of anger-scrambling syndrome. |
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