The Relationship Between TCM Syndrome Type And Metabolic Index Of Type 2 Diabetes With Osteoporosis

Objective:We retrospectively studied the clinical indexes and TCM syndrome of patients with type 2 diabetes mellitus,to investigate the clinical characteristics and the features of TCM symptomatology of type 2 diabetes patients with osteoporosis and the correlation between TCM syndromes and clinical index,and to provide a basis for the prevention and treatment of type 2 diabetes mellitus with osteoporosis by Integrated Traditional Chinese and Western Medicine.Methods:In this study,156 patients with type 2 diabetes mellitus in the Department of endocrinology of Guanganmen hospital from December 2015 to October 2016 were included in the study,according to the bone mineral density test,the patients were divided into normal bone mass group(T?-1),osteopenia group(-2.5<T<-1),osteoporosis group(T?-2.5).To explore the TCM syndrome characteristics of three groups of patients,and analyze the general information between the three groups(such as gender,age,duration,body mass index),blood glucose,bone metabolism and other related indicators,to explore the relationship between them and type 2 diabetes and osteoporosis and the nexus between the clinical indexes and TCM syndrome type.Result:?We collected 156 cases of patients with type 2 diabetes,among them,there were only about 46 cases of osteoporosis,of which there were only about 54 cases of bone loss,and there were only about 56 cases of bone mass.The proportions were 29.5%,34.6%and 35.9%,respectively.In osteoporosis group,qi stagnation and blood stasis were significantly more than the other syndromes,in the osteopenia group,qi stagnation and blood stasis syndrome more than the other syndromes,and in normal bone mass group,liver and kidney deficiency with the highest proportion in the distribution of syndromes,syndrome of the three groups was statistically significant difference(P<0.05).?The proportion of female patients with type 2 diabetes mellitus was higher in the osteoporosis group;? The age of osteoporosis group was higher than that of osteopenia group and normal bone mass group(P<0.05);?The BMI in the osteoporotic group was lower than that in the normal bone group(P<0.05);The levels of ALP,iPTH,?-CTX and BGP in the osteoporosis group were higher than those in the normal bone mass group(P<0.05);UA in osteoporosis group was lower than that in normal bone mass group and osteopenia group(P<0.05);The 24HMA and 24h-uTP in bone mass reduction group were higher than those in normal bone mass group(P<0.05);? There was no significant difference in BMI,HBAlc,FPG,P,Ca,TG,VITD-T,CHO,HDL,ALP,?-CTX,BGP,UA,24h-uTP between the three groups of syndrome types(P>0.05);Qi stagnation and blood stasis 24HMA and iPTH were higher than that of liver and kidney deficiency syndrome(P<0.05);Qi stagnation and blood stasis liver and kidney deficiency syndrome is less than the total hip BMD(P<0.05).Conclusion:?Type 2 diabetes mellitus combined with osteoporosis has the most qi stagnation and blood stasis syndrome,and the most common cases with osteopenia are qi stagnation and blood stasis syndrome,and the bone of normal liver and kidney deficiency syndrome is the highest.The total hip BMD of qi stagnation and blood stasis syndrome is low;?The loss of bone mass in type 2 diabetes is related to gender and age,and is consistent with the reported risk factors for osteoporosis;?Type 2 diabetes with osteoporosis in patients with lower BMI;? ALP,iPTH,?-CTX and BGP in patients with type 2 diabetes mellitus complicated with osteoporosis are higher;?UA in patients with type 2 diabetes mellitus complicated with osteoporosis is lower;?Type 2 diabetes with osteoporosis in patients with higher urinary protein.