| Objective:This study aimed to evaluate the clinical efficacy of chronic primary insomnia in the type of imbalance between heart-yang and kidney-yin with abdominal acupuncture and Estazolam, through observing the influence on Pittsburgh Sleep Quality Index (PSQI). And discuss the mechanism of abdominal acupuncture to treat chronic primary insomnia in the type of imbalance between heart-yang and kidney-yin from plasma 5-hytroxytryptamine (5-HT) levels.Method:Put 60 patients with chronic primary insomnia in the type of imbalance between heart-yang and kidney-yin patients into abdominal acupuncture group (group A) and Estazolam group (group B), who were accord with the inclusion criteria. Give them 4weeks treatment respectively, we measured PSQI before and after treatment and at the end of four weeks of treatment,12 weeks in group A and group B, At the same time, we simultaneous detection of group A and group B 5-HT in plasma before and after treatment and compared with the normal control group, then analyzed the data by statistical methodResult:1. Total scores of PSQI:after treatments, the total scores of PSQI were decreased in both group, which have extreme statistic significance (P<0.001). Abdominal acupuncture therapy group were ascended in the second follow-up, which has outstanding statistic significance (P<0.01); while the Estazolam group were gradually ascended in the first follow-up, which has extreme statistic significance (P<0.001). The total scores of PSQI in the abdominal acupuncture therapy group were apparently lower than the Estazolam group in the post-treatment, the first follow-up and the second follow-up, which have extreme statistic significance (P<0.001).2. Scores of sleeping quality, time for falling sleep, sleep time, sleep efficiency, sleep disorders and day function of PSQI:?Scores of sleeping quality:after treatments, the sleeping quality scores of PSQI were obviously decreased in both group, which have extreme statistic significance (P<0.001). There is no statistic significance in the post-treatment between the two groups (P>0.05); the sleeping quality scores were obviously increased in both group between the first follow-up and the post-treatment, which have extreme statistic significance (P<0.001). As to the second follow-up, there is no obvious ascending in the abdominal acupuncture therapy group when compared with the first follow-up; while the Estazolam group is obviously increased, which has outstanding statistic significance (P<0.01). Scores of sleeping quality in the abdominal acupuncture therapy group are obviously lower than the Estazolam group during the first and second follow-up, which have extreme statistic significance (P<0.001). ?Scores of time for falling sleep: after treatments, the time for falling sleep scores were obviously decreased in both group, which have extreme statistic significance (P<0.001). There is no statistic significance in the post-treatment between the two groups (P>0.05); Abdominal acupuncture therapy group were ascended in the second follow-up, which has outstanding statistic significance (P<0.05); while the Estazolam group were gradually ascended in the first follow-up, which has extreme statistic significance (P<0.05). The total scores of time for falling sleep in the abdominal acupuncture therapy group were apparently lower than the Estazolam group in the first follow-up and the second follow-up, which have extreme statistic significance (P<0.001). ?Scores of sleep time:after treatments, the time for falling sleep scores were obviously decreased in both group, which have extreme statistic significance (P<0.001). There is no statistic significance in the post-treatment between the two groups (P >0.05); Abdominal acupuncture therapy group has no changed between follow-up and the post-treatment, which have no statistic significance (P>0.05); while the Estazolam group were gradually ascended in the first follow-up, which has extreme statistic significance (P<0.001). The total scores of sleep time in the abdominal acupuncture therapy group were apparently lower than the Estazolam group in the first follow-up and the second follow-up, which have extreme statistic significance (P<0.001). ?Scores of sleep efficiency:after treatments, the time for falling sleep scores were obviously decreased in both group, which have extreme statistic significance (P<0.001). There is no statistic significance in the post-treatment between the two groups P>0.05); Abdominal acupuncture therapy group has no changed between follow-up and the post-treatment, which have no statistic significance<P>0.05); while the Estazolam group were gradually ascended in the first follow-up, which has extreme statistic significance (P<0.001). The total scores of sleep efficiency in the abdominal acupuncture therapy group were apparently lower than the Estazolam group in the first follow-up and the second follow-up, which have extreme statistic significance (P<0.001). ?Scores of sleep disorders: after treatments, the scores of sleep disorders were obviously decreased in both group, which have extreme statistic significance (P<0.001). There is extreme statistic significance in the post-treatment between the two groups (P<0.001); Abdominal acupuncture therapy group has no changed between follow-up and the post-treatment, which have no statistic significance P>0.05); while the Estazolam group were gradually ascended in the first follow-up, which has extreme statistic significance (P<0.001). The total scores of sleep disorders in the abdominal acupuncture therapy group were apparently lower than the Estazolam group in the first follow-up and the second follow-up,which have extreme statistic significance (P<0.001). ?Scores of sleep disorders:after treatments, the scores of sleep disorders were obviously decreased in both group, which have extreme statistic significance (P<0.001). There is extreme statistic significance in the post-treatment between the two groups (P<0.001);Abdominal acupuncture therapy group were ascended in the second follow-up, which has extreme statistic significance (P<0.001); while the Estazolam group were gradually ascended in the first follow-up, which has extreme statistic significance (P<0.001). The total scores of sleep disorders in the abdominal acupuncture therapy group were apparently lower than the Estazolam group in the first follow-up and the second follow-up, which have extreme statistic significance (P<0.001).3. The difference between the normal group and the abdominal acupuncture therapy group for both pretreatment and post-treatment reaches the statistical significance,so does the difference between the normal group and the Estazolam group(P<0.001).Conclusion: ?Abdominal acupuncture therapy and oral Estazolam can obviously improve the patient's sleep, reduce the PSQI score, Abdominal acupuncture treatment group is better than that of Estazolam group. ? Abdominal acupuncture therapy and oral Estazolam can obviously improve patients' sleep time a grade, sleep disorder, sleep quality grade, the sleep time, sleep efficiency score, daytime dysfunction, and in terms of improving sleep disorders and daytime dysfunction, Abdominal acupuncture treatment group is better than that of Estazolam group. ?Abdominal acupuncture treatment group at the time of the first follow-up PSQI score has no obvious rise, while the second follow-up obviously increases, the western medicine control group at the time of the first and second time follow-up PSQI scores are obviously higher. Prompt, Abdominal acupuncture long curative effect in treatment group is better. ?Patients with clinical efficacy of chronic primary insomnia in the type of imbalance between heart-yang and kidney-yin, in the peripheral blood the neurotransmitter 5-HT significantly lower than in normal is one of it's characteristics.?Abdominal acupuncture treatment of clinical efficacy of chronic primary insomnia in the type of imbalance between heart-yang and kidney-yin is probably one of the mechanism of improving 5-HT in plasma. |
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