Study On The Syndrome Differentiation Of Allergic Rhinitis And The Intervention Effect Of Compound Yupingfeng Granules

Purpose:With the aid of the ancient and modern clinical literature of traditional Chinese medicine prescriptions database, allergic rhinitis and related symptoms the governance rules of traditional Chinese medicine, to determine the preferred and the commonly us-ed drugs and drugs for; Selected France medicine organic combination of Chinese me-dicine compound.Compound jade screen is validated by animal experiments, the intervention effect of particles on allergic rhinitis model animals, for the treatment of allergic rhinitis small compound optimization and lay a foundation for new drug research and developme-nt as a candidate drugs.Material and method:1 Allergic rhinitis of syndrome standardization studyUsing the Criteria of Diagnosis and Therapeutic Effect of TCM Diseases, Guidel ine for Clinical Research on New TCM Drugs to comparison and analysis, CNKI?wanfang ?weipu database,Combined with clinical's Classification of syndrome different-iation,Reveals the serious problem about Allergic rhinitis syndrome differentiation,Put forward the corresponding solutions2 Compound Yupingfeng granules Effects on experimental allergic rhinitisThe experiment will be 84 male wistar rats were randomly divided into 7 groups,blank group,model group, Zhong Yang control group,west control group?compound Yupingfeng granules low dose group ?compound Yupingfeng granules dose group ?compound Yupingfeng granules high dose group. After the grouping to other groups exce-pt the blank group rats implementation of allergic rhinitis model building. Build mode mainly three stages- based sensitization, strengthening the sensitization and excitatio n-n phase. After the success of the building, sneezing, runny nose on groups of rats s-cratching nose phenomenon observed 30 min, and recorded. After then lavage adminis-tration respectively, all the treatment group continuous dosing 12 d. After the delivery, first of all, each group of rats sneezing, runny nose, scratching nasal symptoms obse-rved 30 min and record. Then the rats fasting overnight, the second day will kill the rat, put off after nasal mucosa in formaldehyde solution, wait aortic blood make high-speed centrifugal, upper serum. Set aside. Data are processed by SPSS 17.0, expresse-d as a`x±s, p < 0.05, with statistical significance.Results:1 Revealed allergic rhinitis syndrome differentiation standard clinical syndrome differentiation and the problems and causes.Comprehensive comparison authoritative literature on allergic rhinitis to establish standard of syndrome differentiation, after eliminating repetitive, take-home lung empty feeling cold syndrome, lung deficiency evil attack qi deficiency syndrome, lung cold syndrome, lung spleen deficiency syndrome, spleen deficiency syndrome, kidney Yang deficiency syndrome, kidney deficiency, kidney Yin deficiency syndrome and lung heat syndrome 9. Academia and to expand the disease differentiation binge to 43. And what distinguishes the symptoms of all CARDS too complicated, chaotic. Allergic rhiniti s symptoms of kidney Yang deficiency syndrome belong to a whopping 57, plenty of virtual of has nothing to do with the disease symptoms. Allergic rhinitis clinical syndrome differentiation syndrome differentiation standard and the seriousness of the probl-em, offset by the disease differentiation diagnosis of objectivity and scientific nature.2 Pharmacodynamic experiment proves that the intervention effect of compound.2.1 Compound jade screen particle behavior influence on model rats.After lavage treatment of each group of rats sneezing, scratching nose, respectivel-y to observe the condition of 30 min, and count the number of sneezing, scratching nose, satisfy the normal distribution of t test, the compound jade screen low dose group of sneezing, scratching nose number have difference compared with model group, c-ompound in the jade screen, high dose group, Xin Qin particles, loratadine group there was a significant difference compared with model group, compound in the jade scree-n, high dose group, Xin Qin particles, loratadine group to change the AR model ratsbehavioral symptoms of treatment effect is significant.2.2 Compound jade screen particle impact on model rat nasal mucosal morphology.Can be seen by the paraffin section of the nasal mucosa, no swelling of the nasa-l mucosa blank group, the mucosa is smooth, compared with the blank group, model group of nasal mucosa is swelling, and inflammatory infiltrates. Small compound low dose group and model group pathological form close, degree of swelling and edema are more severe. Dose group were significantly better, but also accompanied by micro tube rupture. High dose group and control group in the nasal mucosa of organization form is close to blank group, but there is a slight inflammatory infiltrates. That AR disease, caused by mucosal swelling nasal symptoms such as stuffy nose impassability,and inflammatory reaction can also cause the increasing number of nose and the corr-esponding symptoms. After treatment will have different degrees of recovery, but not completely the same as the blank group.2.3 Compound jade screen particle effects on model rats serum IgE.The experimental results show that the blank group rats and model rats serum IgE concentration have significant differences, Ig E as an important index of clinical bloo-d tests to determine the AR, by presenting cells after allergen on, increase the secreti-on of Th2 cells factor, thus inducing B cell differentiation. So the Ig E in the AR model rats obviously higher than that of blank group rats. After medication, loratadine group, the compound particles jade screen high, medium and low dose group of serum Ig E levels have difference compared with model group, suggests that the treatment group after the treatment, to some extent reduce the serum Ig E levels in rats. While from the perspective of numerical Xin Qin serum Ig E levels in the particle group is lo-wer than the model group, but the comparison of statistical software, and no statistica-l significance, showed the Xin Qin particles to reduce the content of serum Ig E and no therapeutic significance.2.4 Compound jade screen particle effects on model rats serum histamine.The experimental results show that the blank group and model group rats serum content of histamine significantly statistical difference, suggests that AR influential tothe body the change of the serum content of histamine. Histamine is a serum immun-oglobulin Ig E, via the blood circulation, and mast cells and basophils, release of nons pecific inflammation factor. Each treatment group after treatment, loratadine, Xin Qin particle group, compound jade screen particles of high, middle dose group compared wi-th model group, all have very significant difference. Showed the above four groups to inhibit histamine secretion to control the treatment of nasal change should response effect is remarkable. Jade screen there are differences between the low dose group and model group, compared with the blank group, also statistically significant hints low dose of treatment effect is not obvious, can't make model rats serum content of his-tamine is reduced to the level of normal rats, illustrates its treatment effect than high,middle dose group.2.5 Compound jade screen particle impact on model rats serum IL-4.Blank group compared with model group rats, the rat serum IL-4 content have ovious difference, confirmed that the AR model rats will due to the stimulation of aller-gen, prompting TH2 cells release of inflammatory factors such as IL-4. The results showed that in loratadine group, Xin Qin particles high, middle dose group with compo-und jade screen to suppress the secretion of rat serum IL-4 has a therapeutic effect,with loratadine group, Xin Qin particles with compound jade screen high dose group compared with model group rats have significant differences, to illustrate the three gro-ups of treatment effect is significant. Compared with average, loratadine group is the best group reduce IL-4 curative effect.Conclusion:1 Allergic rhinitis and anomie is very serious, which leads to the highly discrete clini-cal syndrome differentiation, lost the normalization, standardization and objectification,determining the experience also difficult to the disease diagnosis and treatment. As such, should be through a comprehensive screening, excluding has nothing to do with the disease of virtual symptoms and to abstract out the virtual card, and then establish a complete unity and authority, objective and dialectical criteria of allergic rhinitis.2 Pharmacodynamics experiment, through the literature research combined with clinical screening of jade screen particles, can reduce model rats on the pathogenesis of AR period when nasal symptoms, relieve the pain of the disease; Nasal mucosal swelling degree can reduce the high dose group, physical form close to the blank group, shows that compound particles has good therapeutic effect in change of organization form; I ll Th2 cells secrete inflammatory mediators such as serum Ig E, histamine, serum IL-4,less after treatment level is close to blank group, suggests that small compound with recovery of Th1 / Th2 balance mechanism, effectively reduce the secretion of inflam matory mediators, weakening of nasal mucosa and the stimulation of nerve, thus inhibi-ting the allergic rhinitis attacks. In conclusion that compound jade screen particle has therapeutic effect on allergic rhinitis, summary for the drug laws and provide the exp-erimental basis for screening small organic compound.