Clinical Observation And Safety Study Of Phlegm And Stasis Muscle Healing In Wound Healing After Anal Fistula

Background:"The method of removing slough and promoting growth of tissue regeneration" is the important part in surgical treatment of traditional Chinese medicine, it has been widely used to promote wound healing by doctors in all ages, its clinical effect is significant."Slough" includes the carbuncle-abscess, ulcer, sinuses, sequestrum, foreign bodies, it is the necrotic tissue and the tissue that missing the normal function. Afteroperation of anal fistula, wound surface remains fistula and adhere necrotic tissue, the wound healing is slow. Chinese medical science consider that "no remove of slough, no growth of tissue", we according to this theory, we thought, during the wound healing time "the method of removing slough and promoting growth of tissue regeneration" use to the wound surface afteroperation of anal fistula can promote wound healing and as early as possible to get in to the stage that granulation tissue growth, can shorten the healing time. Shengdan is the representative drug that can remove slough and promote the growth of tissue, because of its toxic reaction, its utilization is gradually decrease and exists clinical problem that its usage have no standard, we select jiuyi-dan on the wound afteroperation of anal fistula, investigate its clinical curative effect and security.Objective:Through the clinical study observe the clinical curative effect and security of the "removing slough and promoting tissue drug" which can promote the wound healing afteroperation of anal fistula. Searching for more better therapeutic method that can promote the wound healing afteroperation of anal fistula, provide some important data for the study of clinical curative effect and security.Methods:The patients with low simple anal fistula come from anal department of Dongfang Hospital Beijing University of Chinese Medicine during September2010and august2011, select60patients who consistent with the bring in standard, randomly divided into treatment group and control group with each30cases, the treatment group treat with prophase jiu-yi dan external application once per day afteroperation. control the wound surface?4cm2and <30cm2.jiuyi-dan dosage is based on the wound areameter, every time2mg/cm2or3mg/cm2, medication day is smaller than14days. Mayinglong Shexiang Zhichuang Gao is used until the wound healing after stop using jiuyi-dan. The control group use Mayinglong Shexiang Zhichuang (iao is used until the wound healing. We reckon the wound area of two sets by membrane method, the verge is bordered by epithelium creeping. Observe secretions, color and luster, pain, wound healing rate, wound healing time, and done the statistical analysis. In treatment group we detect blood mercury and mercury in urine before medication, different node after medication and different node after drug discontinuance, the detection of blood mercury follow up to after drug discontinuance by14days, the detection of mercury in urine follow up to after drug discontinuance by3months, compare the blood mercury level and mercury in urine on different node, the statistical method use SPSS17.0. Observe skin rash, allergy and untoward reaction after use of jiuyi-dan.Results:After four weeks, the recovery rate of treatment group and control group is90%and80%.excellence rate is10%and20%.the curative effect of two sets are all100%. the therapy of two groups all have good effect. The comparison of wound healing time and removing slough time of two sets, the statistical results display. P values are all smaller than0.05. the difference have statistical significance, the wound healing time and removing slough time of treatment group are obviously shortening. Lessening secretions on wound surface and Hushing wound time of treatment group are earlier than control group. The first day and the forth day of jiu-yi dan external application,the pain value of treatment group are obviously higher than control group, prompt that jiu-yi dan external application can stimulate wound aching. During the medication time of treatment group,their has no skin rash, no allergy and no untoward reaction. The blood mercury detection of different node point have no significant deviation from the blood mercury level before medication. The statistical analysis on mercury in urine detection of different node point show that.the mercury in urine level of the first day and forth day after medication, the first day after drug discontinuance.the forth day after drug discontinuance,the twenty eighth day after drug discontinuance are all obviously higher than the mercury in urine level before medication, the comparisons have statistical disparity, the mercury in urine detection of three month after drug discontinuance have no significant deviation from the mercury in urine level before medication. Experiment prompt that small dosage of jiu-yi dan external application have no obvious effect on blood mercury,but can heighten the mercury in urine level, and have significant deviation from the mercury in urine level before medication, the fluctuation of mercury in urine level within the normal range, the detection of mercury in urine on three month after drug discontinuance regain to the level of before medication.and have no skin rash, no allergy and no untoward reaction.Conclusion:The prophase application of removing slough and promoting growth of tissue regeneration on wound surface afteroperation of anal fistula have certain clinical curative effect that can promote wound healing. Tiny dosage of jiu-yi dan short term external application on wound surface Afteroperation of anal fistula is safe and reliable.