The Correlation Between Glioma Locations And The Preoperative Epileptic Seizures: A Systematic Review And Meta-Analysis

Objective To evaluate the relationship between tumor locations in the cerebrum and preoperative seizures in patients with glioma.Methods PubMed,EMBASE,Web of Science,China Biology Medicine,Cochrane Library,CHKI,Wan Fang Database and Wei Pu Database were systematically searched from inception to December,2017,for original studies including reports of preoperative seizures in patients with gliomas in different brain regions.The pooled odds ratio and 95% confidence interval of the meta analysis for preoperative seizure risk stratified by cerebrum regions were calculated.Quality of evidence was assessed per outcome,used the approach of the Grades of Recommendation,Assessment,Development and Evaluation(GRADE).Results Overall,4,323 participants in 16 population-based studies were included in this meta-analysis.Meta analysis indicated that gliomas in the frontal lobe(OR = 1.51,95% CI = 1.09-2.09,P = 0.013)were associated with a higher risk for preoperative seizure compared to occipital lobe involved(OR = 0.53,95% CI = 0.32-0.88,P = 0.014).Regarding the other three lobe involved gliomas,no difference was found between the incidence of preoperative seizures and tumor location.Conclusions Current limited data suggest that frontal gliomas were associated with a higher risk of preoperative seizures,while gliomas in the occipital lobe were associated with a lower seizure risk.Further RCT studies recruiting larger samples sizes are required to validate our result and guide clinical practice.