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Analysis Of Glioma Operation Prognosis Of Epilepsy Seizures

Posted on:2015-03-14Degree:MasterType:Thesis
Country:ChinaCandidate:J LiFull Text:PDF
GTID:2284330431467825Subject:Surgery
Abstract/Summary:PDF Full Text Request
Objective: Summary of supratentorial glioma surgery complicated with epilepsyexperience and therapeutic results provide preoperative epilepsy localization study ofintracranial gliomas on insider merger pathogenesis of epilepsy and epileptic; discussionwith epilepsy as the first symptom of glioma surgery patients, providing an effectivetreatment plan.Methods: By2008March~20103menstrual follow-up operation treatment ofpatients with epilepsy in160patients with supratentorial gliomas (Pathology), analysisof the clinical data, using SPSS statistical software, Logistic multiple regressionanalysis was used to select variables on complicated epilepsy had statistical significance.Analysis of age, gender, symptoms, course of disease, a history of epilepsy, positivesigns, lesion location, take the operation approach, intraoperative cortical vascularinjury, stretch, postoperative cerebral edema, pathology, tumor recurrence, radiotherapy,intraoperative cortical whether electrocautery and tumor removed factors as possible asargument, seizures as the dependent variable. Preoperative cranial CT and MRIexaminations in addition to the regular line, has carried out a routine EEG examinationand long range simultaneous video-EEG examination. Analysis of tumor resectionextent epileptogenic methods, methods to control influence of the severity andprognosis of epilepsy. Postoperative prognosis of epilepsy classified by Engel standardsoutcome: I-96cases: seizures disappear, except for early postoperative epileptic seizures;level II-36cases: seizures rarely or almost disappear; grade Ⅲ-16cases: worthy ofimprovement (90%reduction in seizure frequency), IV-class12: improvement is notevident. Results: Tumor excision in128cases,96patients (81%) in the intraoperativeelectrocorticography (ECoG) under the supervision of surgical resection, epilepsydisappear completely, and only8of the32cases of incomplete resection (54%) seizuresdisappeared completely. Surgery in the tumor resection of degree and prognosisepilepsy attack has statistics meaning (P=0.040); surgery Qian daily epilepsy attack <1times who for86%(ninety one-one hundred and twenty eighths), and daily are attack≥1times who for56%(seventeen-thirty seconds), epilepsy attack frequency and epilepsyprognosis has statistics meaning (P=0.048); simple tumor resection of56cases in thesurgery Hou is not occurred epilepsy38cases (54%), and tumor resection plus MST of90cases in the has72cases surgery Hou epilepsy disappeared (82%).Total and subtotaltumor resection of epileptogenic focus is divided into two groups, for epilepsy controlcompares the satisfaction rate, a statistically significant difference (P<0.05). Singletumor resection, total satisfaction rate and prognosis of total resection of epilepsycontrol, a statistically significant difference (P<0.01). While in epileptogenic focus inboth cases, tumor total resection and complete seizure control with partial satisfactionrate, the difference was not statistically significant (P>0.05, see table4).Conclusion: Craniotomy is an effective method of treatment for Glioma withepilepsy, preoperative accurate positioning is key to the treatment of the epileptogenicfocus. Ask for details before operation in patients with epilepsy history analysis withclinical symptoms, a comprehensive system of physical examination and imaging (CT,MRI, etc) and laboratory tests, a clear positive effects on etiological diagnosis andclinical treatment. Epilepsy in glioma patient controlled removal of lesions and seizuresare equally important.For surgical treatment epilepsy merger of glioma patients, themana in all tumors, and in accordance with intraoperative cortical brain powermonitoring (ECOG) thorough treatment to pre-eclampsia stoves. pre-operative topre-eclampsia stoves the accurate positioning, select the appropriate operation of therouter and surgical methods and techniques for the lesions and the pre-eclampsia stovesand is ideal for pre-post and effective approach. pre-operative epilepsy history length,seizures, frequency, Tumor Size, tumor week brain tissue edema, intraoperative surgeryin the way, tumor excision and skin is electrocautery and post-operative pathologicallevels, brain edema, tumor relapse, and seizures, closely related to the patient’sprognosis, quality of life is directly affected. Postoperative epileptic patients in neurological rehabilitation and quality of life are affected. The health guidance foreducation can be improved with the help of a psychiatrist in postoperative patients withanxiety, depression and other emotions, promote mental and physical health, therebyimproving the quality of life.
Keywords/Search Tags:Glioma, Epilepsy, Epileptic focus, Surgical treatment
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