The Epidemiological Preliminary Pathogenesis Investigation And Analysis Of 132 Cases Congenital Auricle Malformation In Ningxia

Objective To survey the phenotype features of the congenital auricle malformation in Ningxia,and identify the risk factors associated with congenital auricle malformation,we may could provide its preventive measures,risk factors and the science bases for the further relevant research.Method 1.We collected cases of examination visible auricle malformation 132 patients from the otolaryngology head and neck surgery clinic of Ningxia medical university in October 2016 to January 2018.2.A questionnaire was made from retrievalling literatures about risk factors in congenital auricle malformation,and applied to help the otolaryngology physician record the information of patients`parents after we getting the patients and their families informed consent right.2.The paired group people were collected according to age range,from the department in the hospital,without congenital auricle malformation,including 132 patient cases,and the standard questionnaire survey were conducted to their parents.3.Thought case-control retrospective analysis method,the relevant independent variable ill factors and the variable relations between the case group and the paired group to be explored.The meaningful independent impacts on the congenial auricle malformation were checked by binary logistic regression analysis to contributing the risk model for predicting the risk.Results 1.There was no significant difference comparing the age distribution between the case group and the paired group(p > 0.05).2.On the ethnicdistribution,the family education background,the folic acid supplement of 1month before conceive and the first 3 months of pregnancy,the family history of ear deformity and pregnancy residences were proved different between the case group and the paired group(p < 0.01).3.In both group,the aspects of congenital auricle malformation including the patients gender,birth order,birth weight and pathway delivered,whether or not their biology mother had suffered infection,high fever,as well as what drugs they had used during pregnancy,even the mother pregnancy illness,an abortion history resulted from abnormal checking conclusion or spontaneity,the childbearing age,smoking and drinking history of the patients birth father and mother no different were found(p > 0.05).4.The final binary logistic regression analysis revealed that the facts of nation for the Hui ethnic,the place of pregnancy residence in the town,the family education background for junior middle school are the following risk factors,and the Han ethnic,the residence in the rural,high school and above family education background,supplement folic acid are protective factors.Conclusion The risk factors associated with congenital auricle malformation include : Hui ethnic,parents with lower education,no supplement from 1 month before conceiving and the first 3 months of pregnancy,living in towns during the pregnancy.The Han ethnic,residence for the rural,being equal and greater than high school family education background,folic acid supplementation are protective factors.