Study On The Correlation Between Serum C-reactive Protein,IL-6 And IL-10 In Elderly Patients With COPD And Changes Of Pulmonary Function

Objective:More and more people suffering from respiratory diseases,with the continuous progress of the modernization process,a large number of automobile exhaust emissions,winter heating and other reasons,the northern city of winter haze weather continues to appear.Chronic obstructive pulmonary disease?COPD?is one of the most common respiratory diseases.COPD is a chronic disease characterized by incomplete reversible airflow limitation and can be divided into stable and acute progression,but chronic progressive disease that can be intervened by a certain treatment.COPD mainly involved in the lungs,but also can cause the organs and systemic adverse reactions.COPD is one of the common chronic diseases in elderly patients in China.It has great influence on the quality of life.COPD can cause serious adverse events if there's no timely treatment in acute progress,such as shock and death.It was well known that forced expiratory volume in 1 second?FEV1?can reflect the severity,but this value does not fully reflect the patient's overall physical condition.And the improvement of the disease is not limited to the recovery and improvement of lung function.At the same time,for the elderly patients,frequent pulmonary function tests will add to the psychological and cost burden and result in coordination with the medical workers to check their bodies.For elderly patients with COPD,the presence of infection is the leading cause of disease progression,and serum C-reactive protein?CRP?,interleukin 6?IL-6?and interleukin 10?IL-10?A relatively sensitive indicator of the level of infection in the body.This study investigated the expression of inflammatory cytokines in patients with COPD in different grades of our hospital,and explored the correlation between the expression of CRP,IL-6 and IL-10 and the changes of pulmonary function.Then it will provide some data support for the further study.Methods:Patients were randomly selected from the department of respiratory in Bethune International Peace Hospital in Hebei Province from September 2016 to December 2016.At the same time,the healthy elderly people who were hospitalized at the same time were selected as the control group.In this study,COPD patients were divided into four grades according to the revised revision guidelines for chronic obstructive pulmonary disease in2013.In this study,patients were divide intodifferent groups according to the severity of disease.The healthy elderly people with normal physical examination were studied as control group.The results were analyzed by SPSS19.0 data packet.The comparison between the counting data was performed by chi-square test.The measurement data were analyzed by variance analysis and t test.The SNK-q test was used to compare the relationship between the expression of inflammatory factors and the changes of pulmonary function in the serum.The results showed that the correlation between the expression of inflammatory factors and the changes of pulmonary function was the result of multiple linear regression analysis.Results:1 The basic information compared in elderly COPD patients with normal healthy check-up peopleBetween September 2016 and December 2016,by random sampling the intense extract Bethune international peace hospital respiratory hospitalized elderly patients 88 cases,the treatment group were 66 cases,control group were 22 cases;Male patients59,29 in cases.Different grading in elderly patients with COPD and normal elderly patients with the control group in age,sex,and there was no statistically significant,there was no difference between duration distribution as well.There were no difference in these four groups of staff basic information with comparable data.2 The pulmonary function testing analysis contrast results compared elderly COPD patients with normal healthy check-up old manLung function testing division by the same people to have been tested,the result showed:the level COPD1 mean FEV1?%?was59.69�5.32;COPD2 level was 50.88�3.03;44.24�4.66 in COPD3 and 4;The mean FEV1?%?in normal control group was 83.41�4.20,through the analysis of variance,F=346.078,P=0.000<0.05,the results showed that in elderly patients with COPD and normal,healthy check-up of the old man FEV1 distribution difference was statistically significant,normal control group got the highest FEV1?%?,the rest was followed by COPD with mild and moderate COPD group and severe COPD group,through the SNK-q test,which were statistically significant differences between groups.The FEV1/FVC?%?level in COPD1 was 59.09�6.17;COPD2 level was 48.47�3.95;COPD3 and level 4 was 45.57�5.11;Normal control group was 82.85�4.04,F=268.288,P=0.000<0.05,the results show that in elderly patients with COPD and normal healthy check-up old man FEV1/FVC distribution difference was statistically significant,normal control group got the highest FEV1/FVC?%?,the rest was followed by COPD with mild and moderate COPD group and severe COPD group,through the SNK-q test are compared,which were statistically significant differences between groups.3 The serum inflammatory cytokines detection analysis contrast results compared in elderly COPD patients with normal healthy check-up old manDetected by the same people for different groups of the elderly was used to examine the serum levels of inflammatory factors,operation results show that the average CRP level in COPD1?mg/l?group was31.05�7.08;COPD2 level was 39.83�9.14;COPD3 and level 4 was61.59�10.85;Normal control group was 3.07�0.84,through the analysis of variance,F=215.980,P=0.000<0.05,the results show that in elderly patients with COPD and normal healthy check-up old man CRP distribution was statistically different,CRP levels was minimum in normal control group,the mild group,the COPD moderate COPD group and severe COPD group,in turn,increased,and the differences between groups were statistically significant.The IL-6?pg/ml?level in COPD1 group was 13.16�0.53;COPD2level was 13.89�0.94;COPD3 and level 4 was 15.95�1.09;Normal control group was 7.10�0.56,through the analysis of variance,F=445.441,P=0.000<0.05,the results show that in elderly patients with COPD and normal healthy check-up,IL-6 distribution difference was statistically significant,IL-6 was minimum normal control group,two comparison results show that except for COPD mild and severe groups expressed no sense difference of statistics,the difference had statistical significance between other groups.The IL-10?pg/ml?level in COPD1 group was 44.81�1.33;COPD2level was 38.89�0.94;COPD3 and level 4 was 38.16�0.73;Normal control group was 71.86�5.53,through the analysis of variance,F=632.519,P=0.000<0.05,the results show that in elderly patients with COPD and normal healthy check-up,IL-10 distribution were statistically different,two comparison results show that except for COPD mild and severe groups expressed no sense difference of statistics,the difference had statistical significance between other groups.4 The relevance between elderly COPD patients about pulmonary function results with serum inflammatory factorsWe treat CRP,IL-6 and IL-10 respectively as the independent variable,the FEV1?%?and FEV1/FVC?%?as dependent variable,through bivariate Pearson correlation analysis results:CRP contact FEV1?%?of the column number was 0.851,P=0.000;IL-6 and FEV1?%?of column connection number was 0.739,P=0.000;IL-10 and FEV1?%?of column connection number was 0.764,P=0.000.Between CRP and FEV1/FVC?%?of column connection number was 0.573,P=0.000;IL-6 and FEV1/FVC?%?of column connection number was 0.489,P=0.000;IL-10 and FEV1/FVC?%?column connection number was 0.567,P=0.000.The serum CRP,IL-6 and IL-10 as the abscissa,FEV1?%?as the ordinate,draw a scatter diagram,through the regression analysis results:CRP and FEV1?%?of R² is 0.547,P=0.000;IL-6 and FEV1?%?of R²is 0.583,P=0.000;IL-10 and FEV1?%?of R² is 0.465,P=0.000.5 Through multiple linear regression analysis to explore the serum levels of inflammatory factors with FEV1?%?internal relationsWe treated all the CRP of elderly patients with COPD,IL-6 and IL-10 as independent variables,the FEV1?%?as the dependent variable,through multiple linear regression analysis results showed:CRP and FEV1 has multiple regression?%?,t value is 5.498,P=0.000;IL-6 and FEV1?%?did not exist multiple regression relation,the t value is 0.307,P=0.760;IL-10 and FEV1?%?regression relationship did not exist,the t value is 0.651,P=0.517).Finally multi-factor regression equation is:the FEV1?%?=76.321-0.381�CRPConclusion:1 The level of IL-10 in elderly patients with COPD was significantly lower than that in normal controls,and IL-10 levels were positively correlated with pulmonary function levels as the condition increased lung function and IL-10 levels were significantly decreased.2 Serum CRP and IL-6 levels in elderly patients with COPD were significantly higher than those in normal controls,and serum CRP and IL-6 levels were negatively correlated with pulmonary function levels as the condition increased CRP and IL-6 levels.3Through multiple linear regression analysis to explore the inner relationship between serum inflammatory with FEV1?%?learned that multi-factor regression equation was:FEV1?%?=76.321-0.381*CRP...