The Correlation Analysis Between EOS And Inflammatory Markers,Lung Function In COPD And ACO

Objective:To investigate the correlation between Eosinophil(EOS)and inflammatory markers,lung function in Chronic obstructive pulmonary disease(COPD)and Asthma-COPD Overlap(ACO).Methods:Objects: 500 subjects of COPD patients(ACO included)hospitalized from January 2017 to December 2018 in the Second Hospital of Hebei Medical University were enrolled into this study.Groups: According to EOS%,the count of EOS,glucocorticoids respectively,patients were divided into four groups respectively.EOS%:(1)COPD-L,(2)COPD-H,(3)ACO-L,(4)ACO-H;The count of EOS:(1)COPD-RL,(2)COPD-RH,(3)ACO-RL,(4)ACO-RH;Ways of glucocorticoids using:(1)Group 1: Nebulization;(2)Group 2: Intravenous;(3)Group 3: Nebulization and intravenous;(4)Group 4: Control.Research method: Comparing the levels of neutrophil to lymphocyte ratio(NLR),the count of EOS,EOS%,high sensitive c-reactive protein(hs-CRP)and lung function in groups,to find the correlation between EOS and inflammatory markers,lung function.Data analysis was performed by using the SPSS software program version 22.0.Results:1.There were no difference in gender,age and Body mass index(BMI)in COPD and ACO.2.Smoking index in COPD was longer than that in ACO(P<0.05),but medical history was shorter than ACO(P<0.05).3.Grouping by EOS%,hs-CRP in COPD-L was higher than that in COPD-H and ACO-H(P<0.05),at the same time ACO-L was higher than ACO-H(P<0.05);as for NLR,COPD-RL,ACO-RL were higher than COPD-RH,ACO-RH(P<0.05).4.Grouping by the count of EOS,the level of hs-CRP in COPD-RL was higher than that in ACO-RH(P<0.05),and NLR of COPD-RL,ACO-RL were higher than that of COPD-RH,ACO-RH(P<0.05).5.Grouping by the using of glucocorticoids,forced expiratory volume in one second/forced vital capacity(FEV1/FVC),FEV1% predicted(FEV1%pred)in group 4 were higher than the other three groups(P<0.05),and the level of NLR in group 3 was higher than the others(P<0.05).6.Setting up the multiple linear regression including EOS% as dependent variable,the count of EOS has a positive effect on EOS%,and NLR has a negative effect on EOS%(P<0.05).In correlation analysis,there was a positive linear correlation between FEV1%pred and EOS%(r=0.258,P<0.05);hs-CRP,NLR were negatively correlated with EOS%(r=-0.284,-0.477,P<0.05);besides,hospital stay and oxygenation index had a weak correlation with EOS%(r=-0.093,0.096,P<0.05).Conclusion:1.Smoking history of COPD was longer than ACO,but the medical history was shorter than ACO.2.EOS% was negative correlation with inflammatory markers,positive correlation with lung function,and NLR got a negative correlation with EOS%.3.The using of glucocorticoids could be depended on the severity of COPD and ACO.4.There were no significant difference of factors in groups divided by EOS% and the count of EOS,respectively.And more research are needed to identify the critical value of EOS;There were no significant difference between the high-level-EOS group in COPD and that in ACO,which may indicated that COPD and ACO share the same formation mechanism.It remains to be explored.