Single Center Analysis Of Helicobacter Pylori Infection And Related Factors In Patients With Upper Gastrointestinal Diseases In Tibet

Objectives Helicobacter pylori infection is one of the common chronic infections.It is the most common infectious pathogen in the up-per gastrointestinal diseases.It is involved in the pathogenesis of chronic gastritis,gastric and peptic ulcer and gastric cancer.More than half of the world's population is infected.The infection rate varies from country to region.There are few reports on H.pylori infection and related factors in patients with upper gastrointestinal diseases in Tibet area.The region?average elevation 4000 m?is located in the plateau.Because of the unique plateau climate,eating habits,economic conditions,health con-ditions,education and other related factors,understanding of the region H.pylori infection status and distribution characteristics,is essential for the prevention and eradication of H.pylori infection.The aims of this study is to analyze the status and related factors of Helicobacter pylori infection in patients with upper gastrointestinal diseases in Tibet,and provide clinical evidence for its prevention and treatment.Methods A retrospective analysis study collected of the clinical data of 4931 patients with upper gastrointestinal diseases in the ¹³C Breath test(¹³C-UBT)and electronic gastroscopy routine examination in the people's Hospital of Tibet Autonomous Region in from January2016-to December 2017.Clinical charateristics of H.pylori infection in Tebit were analyzed based on these data.Among them,181 patients were randomly selected for their questionnaire survey.Risk factors of H.pylori infection were analyzed.Results?1?H.pylori infection of the subjects In clinical common upper gastrointestinal diseases,the highest infection positive rate of H.pylori was 86.4%from compound ulcer,and the lowest was from re-flux esophagitis?46.9%?.Other upper gastrointestinal diseases was in the rang of 54.5%-78.8%.The total positive rate of H.pylori was 59.4%,male had a higher positive rate than femal?60.8%vs.56.6%,p<0.05?.The positive rate of H.pylori in Tebit and Han-chinese was62.0%and 40.9%,respectively.The difference was statistically signifi-cant?p<0.05?.The patients rates in the group of age?20,21-30,31-40,41-50,51-60,and>60 years old were 67.1%,68.4%,63.8%,55.2%,50.8%,42.3%,respectively.The difference between each group was sta-tistically significant?P<0.05?,with 21-30-year group was the highest.271 cases of chronic gastritis were diagnosed by gastroscopy,and pa-thology.The positive rate of H.Pylori in chronic atrophic gastritis was57%,which was significantly higher than that of chronic superficial gas-tritis.The difference was statistically significant?P<0.05?.The positive rate of H.pylori was correlated with inflammatory activity and tLamina propria lymphoid follicular formation,and the difference was statistical-ly significant?P<0.05?.There was no significant correlation between intestinal metaplasia and H.Pylori infection rate?P>0.05?.?2?Risk factor analysis of H.pylori infection Single-factor analysis showed that the history of stomach disease?P=0.008?,smoking?P<0.01?,regular consumption of tsampa?P=0.001?,regular drinking shortening tea and?or?sweet tea?P=0.007?,often to public teahouse?P<0.01?,Resi-dence?P<0.01?were the independent risk fators of H.pylori infection.Logistic analysis showed that the history of stomach disease,smoking,often eating tsampa,often to public teahouse,Residence were inde-pendent risk factors for H.pylori infection,OR value and its 95%CI were2.25?1.05-4.83??3.94?1.73-8.96??2.88?1.15-7.19??3.40?1.55-7.49?and 4.45?2.03-9.80?,respectively.Conclusion The positive rate of H.pylori in patients with upper di-gestive tract diseases in Tibet was 59.4%.Among the patients with dif-ferent upper gastrointestinal diseases,the H.pylori positive rate in peptic ulcer group was the highest,while reflux esophagitis was the lowest.The H.pylori infection rate was different in different gender,nationality and age.In chronic gastritis,the positive rate of H.pylori in chronic atrophic gastritis and chronic superficial gastritis was different.The pos-itive rate of H.pylori was different from that of inflammatory activity and lamina propria.The history of stomach disease,smoking,regular eating tsampa,often going to public teahouse,residence were inde-pendented risk factors of H.pylori infection.