Relationship Between Vitamin D Status And Metabolic Syndrome Among Middle-aged And Elderly Chinese Individuals

Objective To explore the relationship between vitamin D status and metabolic syndrome(MS)and its components among middle-aged and elderly Chinese individuals.Methods Taking advantage of the baseline data of the "Reaction" study in the Gansu region,We select a total of 9760 eligible residents,Then we extract some data about questionnaires,physical examinations and biochemical tests(including 25-hydroxyvitamin D(25(OH)D),blood sugar,four items of blood lipid,liver and kidney function,etc.)of them to analyse.the modified US National Cholesterol Education Program Adult Treatment Panel III criteria(NCEP-ATPIII)was used to calculate the prevalence of MS and its components.The vitamin D status was divided into three groups according to the concentration of serum 25(OH)D:vitamin D deficient group,vitamin D insufficient group and vitamin D sufficient group.Pearson correlation analysis and multivariate Logistic regression analysis were used to explore the relationship between vitamin D status and metabolic syndrome.Results(1)Among the 9760 subjects,2835 subjects were male(29.05%)and 6925 subjects were female(70.95%);The mean age of the all subjects was(57.97±8.52)years.The prevalence of MS was 51.3%,and there was no difference between male and female(51.0% vs 51.5%,P>0.05).(2)In the survey population,the mean concentration of 25(OH)D was(16.39±6.98ng/ml);The proportion of vitamin D deficiency,insufficiency and sufficiency were 75.1%,22.7% and2.2%,respectively;The prevalence of MS in vitamin D deficient group was higher than that in vitamin D sufficient group and vitamin D insufficient group(P<0.05).(3)Compared with non MS group,the 25(OH)D levels in MS group were lower(15.88 vs 16.90ng/ml,P<0.05),and the prevalence of vitamin D deficiency was higher(77.6% vs 72.4%,P<0.05);with the components of MS increasing,the 25(OH)D levels were decreasing,and the prevalence of vitamin D deficiency was increasing.(4)Pearson correlation analysis showed that: Plasma 25(OH)D levels was negatively correlated with WC,TG,SBP,and the correlation coefficients were-0.021,-0.049,-0.035,respectively(all P<0.05).(5)Binary Logistic regression analysis showed that:After adjusting multiple confounding factors,vitamin D deficiency was associated with increasedrisk of MS(OR=1.422,P<0.05),vitamin D deficiency was associated with increased risk of central obesity(OR=1.424,P<0.05),vitamin D deficiency was associated with increased risk of hypertriglyceridemia(OR=1.369,P<0.05),and this characteristic was more prominent in the male crowd.Conclusions Vitamin D deficiency can increase the risk of MS,central obesity,and hypertriglyceridemia.