The Status Of Vitamin D And Its Relationship Between Cardiovascular Disease In Middle-aged And Elderly People In Rural Areas Of Henan

ObjectiveTo investigate the nutritional status of vitamin D in middle-aged and elderly people in rural areas of Henan Province;to explore the influencing factors of vitamin D deficiency;to identify the correlation between vitamin D deficiency and cardiovascular diseases and discuss its possible mechanism.Thus providing a theoretical basis for the prevention of vitamin D deficiency and cardiovascular diseases.MethodCluster sampling was used to select 3 districts in Zhengzhou Houzhai town,Jiaozuo Wushe country and Luoyang Xin'an country.A total of 2377 middle-aged and elderly people were selected as the research objects.All the subjects were required to complete the health survey,including the general demographic characteristics,life Physical examination;at the same time we test the biochemical indicators of the subjects.SPSS 22.0 software was used for statistical analysis.Quantitative data were described by the mean ± standard deviation(?x ± s),qualitative data described by percentage or constituent ratio;quantitative data between groups using t test or analysis of variance,qualitative data between groups to choose the chi-square test,and finally Using multivariate Logistic regression analysis to explore the influencing factors of vitamin D and cardiovascular diseases.Results(1)2224 subjects were deemed eligible and included in the study,including 1,033(46.4%)males and 1191(53.6%)females;the age was 52.2 ± 17.4 years old;the level of culture is mainly for farmers below junior high school;the level of vitamin D is obvious lower in high-age population,farmer population,waist-to-hip ratio abnormal population and education level in primary school and below is than other populations;those who do not drink,and do not eat or eat less pickles have higher levels of vitamin D than those who consume more pickles.(2)The average 25(OH)D3 level was 27.55±22.43 ng/mL in all the population,and the male vitamin D level was significantly higher than that of females;1170(52.6%)of the vitamin D deficiency in all the population,vitamin D deficiency and sufficient were 562(25.25%)people and 492(22.1%),respectively;the average fasting blood glucose and insulin resistance index of the respondents were the highest in the vitamin D deficiency group,and gradually decreased with the increase of vitamin D concentration;the rate of vitamin D deficiency and deficiency were higher in the population of TG abnormalities,HDL-C abnormalities,and dyslipidemia,and the difference was statistically significant(P<0.05).(3)Multi-factor regression results of vitamin D influencing factors showed that serum vitamin D levels were higher in smokers,and HDL-C,labor,excessive pickles intake,waist-to-hip ratio abnormalities and BMI ? 28 were risk factors for vitamin D deficiency.(4)The number of cardiovascular diseases among the respondents was 986(44.3%),the number of strokes was 152(6.8%),the number of patients with hypertension was 882(39.6%),and the number of patients with coronary heart disease was 179(8.1%),the number of diaetes patients was 369(16.6%),and the levels of vitamin D in patients with cardiovascular disease,stroke,hypertension,coronary heart disease and diabetes were significantly lower than those in the normal population(P<0.05).(5)Case-control results of cardiovascular disease showed that the abnormal proportion of age,waist-to-hip ratio in the case group was significantly higher than that in the control group,and the proportion of smoking,drinking and heavy physical activity was significantly lower than that of the control group.(6)There was a statistically significant difference in the incidence of cardiovascular disease and hypertension between the three groups of vitamin D deficiency,deficiency and adequateness.Trend analysis showed that the risk of hypertension and cardiovascular disease was reduced in the vitamin D deficiency group compared with the vitamin D deficiency group.After adjusting for confounding factors,the OR values were 0.69(0.54,0.87)and 0.76(0.60,0.96),respectively.The dose-response relationship was shown when serum vitamin D levels were below 20 ng/mL,vitamin D and hypertension,cardiovascular There is a dose-response relationship in the risk of disease.As the level of vitamin D increases,the risk of cardiovascular disease and hypertension gradually decreases.(7)The multi-factor analysis of cardiovascular disease showed that the risk of cardiovascular disease was low in severe manual workers.Age >60 years old,TG abnormality,BMI?28 and waist-to-body ratio were all risk factors for cardiovascular disease.Conclusions(1)The deficiency and insufficiency rate of vitamin D were 52.6% and 25.3% in rural areas of Henan Province,the problem of vitamin D deficiency in elderly person of Henan Provence was serious.Vitamin D deficiency in the female population is significantly higher than male,and age,BMI,and dyslipidemia were important risk factors for vitamin D deficiency,while vitamin D levels in smoking and drinking groups are relatively high.Reasonable measures should be developed to prevent and improve the status of vitamin D deficiency.(2)Vitamin D deficiency lead to increased risk of hypertension,diabetes and cardiovascular disease.When vitamin D is less than 20 ng / ml,there is a dose-response relationship between vitamin D and the risk of hypertension and cardiovascular disease.