| BackgroundAngina is a common symptom of coronary atherosclerotic heart disease(coronary heart disease).It is still repeated after western medicine treatment of standard anti-angina pectoris,which seriously affects the quality of life of patients.Some symptoms are not due to a single angina.This is because some patients with angina have a series of psychological reactions that lead to the above symptoms.Previous studies have shown that XinKeShu tablets have the effect of relieving anxiety,depression and other adverse emotions while improving the symptoms of angina,but the relevant research on XinKeShu tablet for stable angina pectoris(Qi-stagnation or Blood Stasis Type type)related research indicators is continuous,continuous Observed clinical symptoms,quality of life,changes in serological indicators rarely reported.Objective Objective to observe the effect of XinKeShu Tablet on clinical symptoms,TCM syndromes,quality of life,and anxiety and depression state of patients with stable angina in a short period of time,and to determine serum Noradrenaline(NE)levelsand serum homocysteine(HCY)level,assess the timeliness of treatment,guide the clinical rational and standardized medication.MethodsWe collected 120 patients with stable angina pectoris(Qi-stagnation or Blood Stasis Type)who were treated in our hospital from January 2017 to December 2017 and were randomly divided into control group and treatment group,60 cases in each group.The control group was given conventional treatment.The treatment group was given XinKeShuTablet on the basis of conventional treatment,1.24g(4 tablets)/time,3 times a day for 12weeks;observe the symptoms of angina pectoris for 4 weeks,8 weeks,12 weeks and prior treatment,changes in the TCM syndrome scores,ECG,Seattle Angina Scale,Anxiety Depression Scale,the scores of predepressive symptoms,European Five-Dimensional Health Scale(EQ-5D),serum NE,serum HCY,etc.Safety indicators include adverse events,blood routine,liver and kidney function.Using SPSS19.0,measurement data were expressed as mean standard deviation,count data were expressed as percentages,and count data were compared using chi-square test.Measurement data were compared between two groups using two independent samples t-test,test level ?=0.05,P<0.05.That is the difference is considered statistically significant.Results1.Baseline situation: Demographic characteristics of the two groups include gender,marriage,ethnicity,age,height and weight.There was no significant difference(P>0.05)in angina pectoris score,Seattle scale score,anxiety and depression scale score,EQ-5D score,TCM syndrome score,NE level,HCY level and physical and chemical indicators.2.Clinical efficacy:2.1 The total effective rate of the efficacy evaluation of angina pectoris symptoms after treatment in both groups showed a gradually increasing trend,and there were differences at all time points(P<0.05).The total effective rate of efficacy evaluation of cocaine symptoms at each time after treatment in the treatment group was higher than that of the control group(P<0.05).2.2 The exercise load,metabolic equivalents,and average exercise time of both groups showed an upward trend,and there were differences at all time points(P<0.05).The maximum amplitude of ST-segment depression after treatment in both groups showed a downward trend,and each time There were differences in points(P<0.05).After treatment,the exercise load,metabolic equivalent,mean exercise time,and the maximum amplitudeof ST segment depression were better in the treatment group than the control group(P<0.05).2.3 The total effective rate of electrocardiographic evaluation after treatment in both groups showed a gradually increasing trend,and there were differences at all time points(P<0.05).The total effective rate of electrocardiogram evaluation at each time after treatment in the treatment group was higher than that of the control group(P <0.05).2.4There was no difference in the weekly consumption of nitroglycerin between the two groups(P>0.05).The weekly use of nitroglycerin in the control group and the treatment groupshowed a gradual downward trend,and there were differences at each time point(P<0.05).The weekly dose of nitroglycerin was lower in the treatment group than in the control group(P<0.05).2.5 Patients in the control group and the treatment group received a gradual increase in the Seattle scale scores after treatment,and there were differences at all time points(P<0.05).The Seattle groupscores were higher in the treatment group than in the control group at each time point after taking the drug(P<0.05);2.6 The scores of TCM syndromes of the patients in the control group and the treatment groupshowed a decreasing trend,and there were differences at each time point(P<0.05).The scores of TCM syndromes in the treatment group were lower than those in the control group at each time point after the treatment(P<0.05);2.7 The treatment group had no difference in mobility,self-care,daily life,and pain scores before/after medication(P>0.05).The anxiety score showed a downward trend and was different at each time point(P<0.05).There was no difference in mobility,self-care,daily life,and pain scores between the control group and the control group(P>0.05),but anxiety scores were lower than those in the control group(P<0.05).2.8 There was no difference in the scores of patients with generalized anxiety disorderscale before and after administration in the control group(P>0.05).The scores of patients with generalized anxiety disorder scale in the treatment groupshowed a decreasing trend,and there were differences at each time point(P<0.05).),The scores of generalized anxiety disorder scales at the various time points after treatment in the treatment group were lower than those in the control group(P<0.05).2.9 There was no difference in the scores of predepressive symptoms before and after treatment in the two groups(P>0.05).There was no difference between the two groups before and after treatment in the Depressive Symptom Inventory(P>0.05).The Depressive Symptom Inventory scores in the treatment group after treatment.There was a gradual decrease trend and there was a difference at each time point(P<0.05).The scores of the Depressive Symptom Inventory at each time point in the treatment group were lower than those in the control group(P<0.05).2.10 Serum norepinephrine and homocysteine levels in the control group before and after treatment were similar(P>0.05);serum norepinephrine levels in the treatment groupshowed a gradually increasing trend after treatment,and each time point had differences(P<0.05): Serum norepinephrine levels in the treatment group were higher than those in the control group at each time point after treatment(P<0.05);serum homocysteine levels in the treatment groupshowed a gradually decreasing trend after treatment,and there was a difference at the time points(P<0.05).The serum homocysteine levels in the treatment group were lower than those in the control group at each time point(P<0.05);3.There was no significant difference in blood routine and liver and kidney function between the two groups(P>0.05).No serious adverse events occurred in either group.Conclusion1.The heart can improve the treatment time,clinical symptoms,depression and anxiety symptoms,improve the quality of life more obviously,Clinical symptoms,depression and anxiety.2.It can improved quality of life may be related to elevated serum norepinephrine levels and decreased levels of homocysteine. |
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