Study On The Effect Of She Medicine Prescription Lipid-Lowering And Protecting Liver Decoction In Treating Phlegm Dampness Type Non-Alcoholic Fatty Liver Disease

Objective The clinical efficacy and safety of she medicine prescription lipid-lowering and protecting liver decoction in treating phlegm dampness type non-alcoholic fatty liver disease(NAFLD),and to explore its mechanism of action.Methods 120 eligible subjects were randomly divided into the basic treatment group,the traditional Chinese medicine(TCM)group and the integrated Chinese and Western medicine group,40 cases in each group.The basic treatment group with exercise,diet and lifestyle intervention and other basic treatment,traditional Chinese medicine group in the treatment group was given on the basis of oral she medicine prescription lipid-lowering and protecting liver decoction oral group in traditional Chinese medicine,were given oral vitamin E soft capsule combined with Western medicine.4 weeks were 1 courses,and 2 courses were observed continuously.The changes of body mass index,blood lipid,liver function,liver B ultrasound and TCM symptom score in three groups before and after treatment were observed,and the adverse reactions during treatment were recorded.Results 1 Intra group comparisonThe BMI index of the three groups decreased significantly compared with that before treatment(P<0.01),and the levels of TC,TG and LDL-C decreased and HDL-C increased(P<0.05),suggesting that the three treatment regimens were effective in improving BMI,reducing TC,TG and LDL-C,and increasing the level of TC.The TCM symptom score in the basic treatment group decreased compared with that before,with statistical significance(P<0.05).There was no significant difference in the improvement of liver function before treatment(P>0.05).It is suggested that exercise diet control can effectively improve the clinical syndromes of traditional Chinese medicine,but there is no obvious effect on improving the liver function.Integral group were significantly decreased symptoms of traditional Chinese medicine combined with traditional Chinese medicine and Western medicine group(P<0.01),improvement in liver function was lower than before the treatment,there was statistical significance(P<0.05),suggesting that simple oral medicine and vitamin E soft capsule combining traditional Chinese and Western medicine therapy can effectively improve liver function and integral on the basis of TCM syndromes in traditional Chinese medicine.2 Inter group comparisonCompared with the basic treatment group,the Chinese medicine group and the integrated Chinese and Western medicine group were significantly better in reducing BMI,TC and TG and increasing HDL-C level,improving clinical comprehensive efficacy,liver B ultrasound curative effect and TCM symptom score(P<0.01).In the improvement of LDL-C,the difference was statistically significant(P<0.05,P<0.01).Compared with the basic treatment group,the Chinese medicine group were significantly better in reducing AST(P<0.01)and ALT(P<0.05),but In the improvement of GGT and ALP,they were effective(P>0.05).Compared with the basic treatment group,the integrated Chinese and Western medicine group were significantly better in reducing AST,ALT(P<0.01)and GGT,ALP(P<0.05)Chinese medicine group and combination of Chinese medicine and Western medicine group had a similar effect on improving BMI,blood lipid and liver function.,clinical efficacy,liver B-ultrasound curative effect and improving TCM symptom score.The difference was not statistically significant(P>0.05).Conclusion She medicine prescription lipid-lowering and protecting liver decoction in the treatment of phlegm dampness type NAFLD has good curative effect,can reduce the body mass index,patients to correct lipid metabolism,improve liver function,improve liver imaging,alleviate the clinical symptoms of the patients,and the combination of traditional Chinese and Western medicine and the treatment group efficacy,no adverse reactions,is a traditional Chinese medicine preparation safety and no toxicity.