| Objective :Clarifying the academic thought of Professor Zhang Jianjun in the treatment of liver cancer by sorting out clinical data and summarizing the clinical ideas and experience.To explore the clinical effect and symptom improvement of "Fuzheng Jiedu Sanjie Fang" originated from Professor Zhang in the treatment of primary liver cancer,and compared with the simple western medicine group,objectively evaluated its efficacy and safety,and provide evidence-based evidence for the treatment of liver cancer.Method:Using a retrospective study,300 patients with primary liver cancer who had a survival period of more than two years in the Department of Liver Diseases,Oncology Clinic and Inpatient Department of the Third People's Hospital of Hubei Province were selected.According to the BCLC stage,it is divided into early hepatocellular carcinoma and middle-late hepatic carcinoma,on the basis of the treatment methods,they were divided into traditional Chinese medicine therapy group and simple western medicine group,in which the Chinese medicine therapy group used Fuzheng Jiedu Sanjie Fang as the basis for addition and subtraction with conventional western medicine,while the western medicine group was the control group.The middle-late group was further subdivided into five groups: liver qi stagnation group,damp heat accumulation group,blood stasis block group,liver depression spleen deficiency group,liver and kidney yin deficiency group and western medicine control groups.The changes in solid tumors before and after treatment in each group,changes in serological parameters,physical fitness scores,and improvement of TCM symptoms were evaluated.Result:The difference of ALT,TBIL,ALB and AFP between the two groups in the early liver cancer group was statistically significant(P<0.05),and the ALT and ALB values of the control group and the experimental group after treatment were also significant.Statistical significance(P<0.05)showed that TCM treatment had obvious repair of hepatocytes and improved hepatic synthesis.The KPS score in the experimental group was significantly increased after treatment,and the difference was statistically significant before treatment(P<0.05).There was a gradual improvement in the upward trend within 2 years,but there was no significant difference between the three months after treatment,one year,and two years after treatment.There was no significant difference in the clinical benefit rate between the experimental group and the control group,indicating that there was no significant difference in the improvement of solid tumor size between the two groups.The total effective rate of TCM syndromes in the experimental group was 90.9%,which was higher than the control group 60%,and the difference was statistically significant(P<0.05),suggesting that the treatment group was better than the control group in improving the symptoms.There were 170 subjects in the middle and advanced stage liver cancer group.There were no statistically significant differences in the pre-treatment serological indicators between the TCM syndrome groups,and they were comparable.Compared with before treatment,there were differences in the levels of ALT,TBIL,ALB,and AFP in each group.The TBIL value was statistically significant in the blood stasis group compared with other groups(P<0.05);compared with before treatment,the blood stasis group was treated for 3 months There was a statistically significant increase in KPS score(P<0.05).No statistical difference was found in the other groups.The KPS scores in one year and two years after treatment in the blood stasis block group were compared with those after three months of treatment.The difference was not statistically significant(P>0.05).The clinical benefit rate of blood stasis type has the highest CBR(91.7%),and the difference between the two groups is statistically significant(P<0.05).At the same time,the overall improvement rate of TCM symptoms in the blood stasis group is the highest.It was 83.3%,but there was no significant difference compared with other syndrome groups(P>0.05).The results suggest that the internal blood stasis group has significant clinical effects in improving the TBIL value of patients and the remission of TCM symptoms. |
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