| Objective:To evaluate the clinical efficacy of 60 patients with spleen deficiency chronic atrophic gastritis before and after treatment by strengthening spleen and Invigorating Qi,and to provide a basis for clinical application.Clinical data:From October 2015 to September 2017,the patients with chronic atrophy diagnosed by gastroscopy and pathology were diagnosed by gastroscopy and pathology in the outpatient department of the integrated traditional Chinese and Western Medicine Hospital of Jiangsu province from October 2015 to September 2017,and 60 cases of spleen and stomach weakness syndrome were treated by traditional Chinese Medicine system.Among them,there were 27 male and 33 female,the oldest one was 75 years old and the youngest was 30 years old,the average age was 55.30 + 10.46(age);the shortest course was 0.5 years,the longest was 30 years,the average course was 4.08 + 4.92(year).Among 60 patients 13 one only had atrophied,41 one had atrophy accompanied by intestinal metaplasia(among them,25 cases were mild,15 cases were moderate,and 1 cases was severe),6 cases had low grade intraepithelial neoplasia.Methods:We will collect the confirmed CAG patients,using the TCM syndrome differentiation for determining the syndrome of spleen and stomach weakness,using the method of invigorating the spleen and invigorating qi and its prescription as the basic treatment.After decocting the decoction orally,each time,250ml,3 times a day,the course of treatment is 3 months.After that,we observe the changes of the symptoms,gastroscope and pathology of the patients before and after the treatment.To compare the therapeutic effects on atrophy,intestinal metaplasia and low-grade intraepithelial neoplasia by using that way.Results:The total effective rate of the method of invigorating spleen and invigorating qi in improving the overall symptoms of TCM was 95%,of which the clinical cure rate was 35%,the effective rate was 38%,the effective rate was 22%;as for gastroscope the clinical cure rate was 20%,the effective rate was 27%,the effective rate was 42%,,the total effective rate was 89%;and d for pathology,the cure rate was 10%,the effective rate was 30%,the effective rate was 42%and the total effective rate was 82%.The clinical cure rate of 13 cases with only atrophy in 60 CAG patients was 8%,the effective rate was 15%,the effective rate was 54%and the total effective rate was 77%;the clinical cure rate of 41 cases of atrophy with intestinal metaplasia in 60 cases was 10%,the effective rate was 34%,and the effective rate was 39%,the total effective rate was 83%.Of the 60 patients with CAG,6 one had atrophy with low-grade intraepithelial neoplasia,the clinical cure rate was 17%,the effective rate was 17%,the effective rate was 33%,and the total effective rate was 67%.After treatment,the integral and total pathological scores were significantly lower than before treatment,and the difference was statistically significant(P<0.05).13 cases of only atrophy and 41 cases of atrophy accompanied by intestinal metaplasia were statistically significant before and after treatment(P<0.05);6 cases of atrophy accompanied by low-grade intraepithelial neoplasia were treated,but there was no significant difference in pathological scores before and after statistical analysis(P>0.05).Conclusion:The method of invigorating spleen and invigorating qi and its prescription have positive effect on the chronic atrophic gastritis of spleen deficiency.It can improve the symptoms of discomfort,gastroscope and pathological changes of gastric mucosa,especially to improve the effect of atrophy and intestinal metaplasia.It may be due to the low sample size for there has been no significant difference for the treatment of low grade intraepithelial neoplasia.This study confirmed the effectiveness of TCM and its prescription on CAG under the premise of syndrome differentiation,but it needs to further increase the sample size,and set up a control to expand the verification. |
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