The Research Concerning The Experience Of Professor Xu Jingfan Treating Bile Reflux Gastritis Based On Data Mining

Objective:With the help of computer technique of data mining,the clinical case records of Professor Xu Jingfan in diagnosing and treating BRG(bile reflux gastritis,BRG)are collected and compiled for a deeper exploration and discussion,in order to enrich the acknowledgement of this disease in the language of TCM(traditioal Chinese medicine,TCM),enhance the ability of clinical diagnosis and treatment,and to advance the therapeutic effect.Method:Referring to the inclusion and exclusion criteria,input the standarded cases for 143 times of treatment,which have been filtrated through data preprocessing,frequency statistics,association rules and clustering analysis,to the Medcase V3.2,with the aim to sum up the experience from Prof.Xu Jingfan of diagnosing and treating BRG,focusing on the analysis and conclusions from the aspects of general information,clinical symptoms,tongue and pulse,pathogenesis and principles of treatment,and prescriptions etc.Results:1.General information:107 candidates,143 times of treatment on aggregate,79 for female,64 for male;Patients mainly range from 30-69 years old,making up three-quarters of the total treatment times.2.Frequency statistics:the clinical symptoms of higher frequency appears to be stomach glomus and distention,stomachache,belching,poor appetite,loose stool,bitter taste,noisy stomach and pharynx discomfort,among which stomach glomus and distention and stomachache are the main manifestations;light red tongue body with white thin tongue coat are the most common tongue nature,with frequencies of 42.66%and 68.53%respectively;pluse are mostly seen as thready and wiry with frequencies of 76.92%and 50.35%respectively;the common pathogenesis are gallbladdr and stomach Qi stagnation,spleen and stomach Qi deficiency,damp-heat retention in middle Jiao and stomach Yin deficiency etc.The most common therapeutic way is regulating Qi to harmonize stomach,still others such as soothing liver to promote gallbladder,reinforcing spleen and stomach,tonifing stomach Yin are frequenly seen as well;There are 41 herbs with use frequency over 12,1591 times on aggregate,the full-range frequency reaching 79.19%.The high-frequency herbs are endothelium corneum,white peony root,bergamot,medicated leaven,etc.The high-frequency herb assortments are regulating Qi herbs,digestant herbs and tonifying Qi herbs etc.3.Association rules:(1)Intra-association between styptoms:high correlations exist in stomachache-stomach glomus and distention,poor appetite-stomach glomus and distention,bleching-stomach glomus and distention etc;Intra-association between pathogenesis:gallbladder-stomach Qi stagnation is the most common pathogenesis,sharing a relative high correlation with damp-heat retention in middle Jiao,mind disturbance and Qi adverse rising etc.;(2)Extra-association between symptoms and pathogenesis are mainly 3 forms:single symptom and pathogenesis,single symptom and multiple pathogenesis,simple pathogenesis and multiple symptoms;Extra-association between pathogenesis and herbs are mainly 2 forms:single pathogenesis and herb,single pathogenesis and multiple herbs.4.Clustering analysis:the 6 pairs of herbs concluded by systematic clustering are bitter orange-lygodium japonicum,white peony root-(baked)licorice,bergamot-endothelium corneum,prepared pinellia tuber-pericarpium citri reticulatae and so on,which are frequently used by Prof.Xu Jingfan.A basic formula is summarized from the experience of Prof.Xu Jingfan to treat BRG with 8 groups of herbs through K-means clustering analysis.5.Academic experience:academic experience from Prof.Xu Jingfan in diagnosing and treating BRG is summarized from multiple aspects including symptoms.Conclusion:According to the results of data mining,we can draw a conclusion that the main symptoms of BRG are stomach glomus and distention and stomachache;the main tongue nature is light red tongue with thin white tongue coat;the main pulse are thready and wiry;the general pathogenesis is gallbladder and stomach disharmony and Qi adverse rising;the key therapeutic way is soothing liver to promote gallbladder and regulating ascending stomach Qi.The basic formula includes bitter orange,white peony root,prepared pinellia tuber,pericarpium citri reticulatae,bergamot,endothelium corneum,lygodium japonicum,coptis chinensis,poria cocos,malt,medicated leaven,(baked)licorice.In addion,we can summarize the academic experience from Prof.Xu Jingfan in diagnosing and treaing BRG,which is well worth spreading and applying widely.