The Impact Of Interaction Between Alcohol Consumption And Obesity On Incident Hypertension

Objective:1?To investigate the effects of alcohol consumption and obesity on hypertension.2?To investigate the interaction between alcohol consumption and obesity on hypertension risk.Methods:1.The participants in the present study were come from the prospective cohort study of“Prevention of multiple metabolic disorders and metabolic syndrome in Jiangsu province”,which was conducted between April 1999 and October 2007.A total of 4083participants completed the five years follow-up survey.Among of them,2778 eligible participants were selected for the present analysis.In the baseline and follow up survey,all of participants completed questionnaire with information on diet,education,occupation,lifestyle factors,and medical history.Data on demographic characteristics,physical examination and laboratory tests were also obtained.2.Cox proportional hazards regression model was used to analyze the association between body mass index(BMI),waist circumference(WC)and waist to height ratio(WHtR).Logistic regression model was used to examine the interactions between alcohol consumption and WC,BMI and WHtR on the risk of hypertension.The relative excess risk due to interaction(RERI),the attributable proportion due to interaction(AP),and the synergy index(SI)were calculated.Results:1.660 patients(254 males and 406 females)were new developed hypertension cases during five years following-up.The mean of WC,BMI and WHtR of the hypertension individuals were(23.3±3.2)kg/m~2,(77.7±9.0)cm and 0.49±0.06,respectively,which were significantly higher than those in normal subjects(22.4±3.0kg/m~2 of BMI,74.8±8.5 cm of WC and 0.47±0.05 of WHtR).2.After adjustment for age,sex,smoking status,family history of hypertension,the HR of hypertension for participants with obesity,high WC,high WHtR and alcohol consumption were significantly higher.The HR(95%CI)for obesity,high WC,high WHtR and alcohol consumption were 1.79(1.46-2.20),1.64(1.32-2.03),1.42(1.15~1.74)and 1.65(1.29-2.12),respectively.3.Among the persons with both abnormal BMI and alcohol consumption,HR(95%CI)of subjects with hypertension was 2.76(2.45-3.17),with 1.60(0.48-5.28)of SI(95%CI),0.66(-0.47-1.79)of RERI(95%CI)and 0.24(-0.22-0.69)of AP.Additionally,HR(95%CI)of subjects with both high WC and current alcohol consumption was 4.93(2.87-8.49),with 4.49(1.97-10.22)of SI(95%CI),3.06(0.48-5.64)of RERI(95%CI)and 0.62(0.41-0.83)of AP(95%CI).Among the subjects with both high WHtR and alcohol consumption,the HR(95%CI),SI(95%CI)RERI(95%CI)and AP(95%CI)was 2.80(1.73-4.59),2.14(0.88-5.17),0.96(-0.40~2.32)and 0.34(0.03-0.68),respectively.Conclusions:1?Obesity,high WC,high WHtR,and alcohol consumption were risk factors of hypertension.2?The impact of an additive interaction of alcohol consumption and high WC on EH risk existed.