The Clinical Observation Of The Diabetic Peripheral Neuropathy Of Lower Limb Of Qi Deficiency And Blood Stasis By Treatment Of Modify HuangQi GuiZhi WuWu Decoction

Objective: To observe the clinical effect and safety of The Diabetic Peripheral Neuro Pathy of Lower Limb of qi deficiency and blood stasis by treatment of Modify Huang Qi Gui Zhi Wu Wu decoction,and analysis from clinical view of the advantage of The Diabetic Peripheral Neuropathy of Lower Limb of qi deficiency and blood stasis by treatment of Modify Huang Qi Gui Zhi Wu Wu decoction.Methods:66 cases of meet the inclusion criteria were randomly divided into two groups(treatment group 33 cases and control group 33 cases)from Henan Province Hos Pital of Traditional Chinese Medicine of encephalopathy and endocrinology Out Patient Department in March 2016 to December 2016.The treatment group were given basic treatment + Modify Huang Qi Gui Zhi Wu Wu decoction Orally + Modify Huang Qi Gui Zhi Wu Wu decoction fumigate-washing.The control group given basic treatment and Mecobalamin Tablets orally and Constant temperature water fumigate-washing.The two groups were treated for 4 weeks.Before and after treatment compared two groups of TCM syndrome score,lower extremity peripheral nerve conduction velocity,Toronto score,blood lipids and homocysteine,so as to evaluate its clinical efficacy.Data analysis were using SPSS21.0 software.Results: 1.TCM syndrome curative effect comparison: the total effective rate of the treatment group was 86.67%,the total effective rate of the control group was 67.67%,the difference between the two groups was statistically significant(P<0.05),the treatment group was better than the control group.2.TCM syndrome score comparison: between the two groups(P<0.05)the difference was statistically significant after treatment,the treatment group was better than the control group.3.Single TCM symptom score comparison: syndrome of limb numbness in the treatment group and the comparison group(P > 0.05),there was no significant difference.Between the control group after treatment group(P<0.05),the difference was statistically significant,indicating that the control group improved limb numbness syndrome than the treatment group;fatigue,shortness of breath syndrome,the control group after treatment,comparison group(P > 0.05),the difference was not statistically significant,the treatment group after treatment.Comparison of intra group and inter group(P<0.05),indicating that the control group in improving the mental fatigue fatigue,shortness of breath syndrome is invalid,treatment group than the control group.Compared with the control group,the others of TCM syndrome were statistically significant differences between the syndrome group and the comparison group(P<0.05 or P<0.01).4.Blood glucose comparison: the control group of FPG and 2h PG after treatment(P>0.05),the difference was not statistically significant.FPG,2h PG treatment group after treatment(P<0.05),the difference was statistically significant,there was significant difference between the two groups after treatment(P<0.05).The results showed that the treatment group was better than the control group in reducing FPG and 2h PG.5.The comparison of four items of blood lipid tests and homocysteine in the two groups:TC,TG,LDL and Hcy levels were decreased comparing with pre-treatment,HDL levels were increased comparing with pre-treatment,the treatment group was better than the control group(P<0.05),the treatment group decreased significantly than the control group after treatment,the differences were statistically significant(P<0.05);The results showed that the treatment group was better than the control group in reducing TC,TG,LDL,Hcy and increasing HDL.6.Comparison of nerve conduction velocity: two groups of right lower limb sensory conduction velocity of common peroneal nerve and tibial nerve conduction velocity and sural nerve before treatment were increased after treatment(P<0.05);between the two groups,the treatment group increased significantly compared with the control group,the difference was statistically significant(P<0.05);the treatment group was better than the control group.7.TCSS score comparison: the TCSS score was lower than the pre-treatment(P<0.05).After treatment,the treatment group was significantly increased compared with the control group,the difference was statistically significant(P<0.05).8.The safety evaluation of the two groups: there was no obvious adverse reaction in the two groups after treatment.Conclusion: 1.Modify Huang Qi Gui Zhi Wu Wu decoction with internal and external treatment can effectively improve the TCM syndromes of patients with diabetic peripheral neuropathy of lower limb of Qi deficiency and blood stasis.2.Modify Huang Qi Gui Zhi Wu Wu decoction with internal and external treatment was better than Mecobalamin Tablets orally in the aspect of improvement of blood lipid,blood homocysteine levels,neurological injury,lower limb nerve conduction velocity.3.Modified Modify Huang Qi Gui Zhi Wu Wu decoction has no adverse reactions in the course of treatment,and it is a safe and effective drug for the treatment of diabetic peripheral neuropathy with Qi deficiency and blood stasis.