Clinical Effect Of Gubu Decoction On Arteriosclerosis Obliterans Of Lower Limbs

Objective:To observe and evaluate the clinical efficacy and safety of Gubu Decoction in the treatment of lower extremity arteriosclerosis obliterans(Qi and yin deficiency,stasis and heat syndrome)in non ulceration stage,and to provide a new idea for the treatment of lower extremity arteriosclerosis obliterans with traditional Chinese medicine.Methods:60 patients with lower extremity arteriosclerosis obliterans(ASO)who met the inclusion criteria in Shandong Provincial Hospital of traditional Chinese medicine from January 2019 to January 2021 were selected and randomly divided into treatment group and control group,30 cases in each group.The control group was given alprostadil injection 10 μg,and Xuesaitong Injection(Luotai)800mg,intravenous drip,once a day.The treatment group was given Gubu Decoction on the basis of the control group.After 4 weeks of continuous treatment,the clinical symptoms,signs,ankle brachial index(ABI),total cholesterol,triglyceride,low-density lipoprotein,high-density lipoprotein and other blood lipids,plasma fibrinogen level(FIB),high-sensitivity C-reactive protein,etc.of the patients before and after treatment were compared and analyzed.Result:(1)Two groups of patients in gender,age and other general conditions,risk factors,symptoms and signs score,ABI,blood lipids,FIB,hs CRP and other aspects were compared,there was no significant difference between the two groups,with comparability.(2)Comparison of clinical symptoms and signs:after treatment,the symptoms and signs of the two groups were improved to varying degrees,which were statistically significant compared with those before treatment.The treatment group could better improve the discomfort symptoms of limb cooling,acid swelling,numbness and intermittent claudication,and better improve the skin temperature,dorsalis pedis artery pulse and other signs,which was worse than the control group The difference was statistically significant(P<0.05)(3)ABI comparison:after treatment,the ABI levels of the two groups were improved in varying degrees,compared with before treatment,with statistical significance.After treatment,the improvement of the treatment group was more obvious,with statistical significance.(4)Comparison of blood lipid:after treatment,the levels of total cholesterol,triglyceride and low-density lipoprotein in the two groups decreased,and the differences were statistically significant compared with those before treatment.After treatment,the differences of total cholesterol and low-density lipoprotein in the treatment group were statistically significant compared with those in the control group.There was no significant difference in HDL between the two groups(P>0.05).(5)Comparison of fibrinogen level:after treatment,the fibrinogen level of the two groups decreased to different degrees,the difference was statistically significant compared with that before treatment,and the difference was statistically significant between the two groups after treatment.(6)Comparison of high-sensitivity C-reactive protein:after treatment,the overall level of high-sensitivity C-reactive protein in the treatment group decreased,the difference was statistically significant,and there was no difference in the control group before and after treatment.Conclusion:On the basis of alprostadil and Xuesaitong,Gubu decoction is used to treat lower extremity arteriosclerosis obliterans of Qi and yin deficiency and internal resistance of blood stasis and heat.Compared with alprostadil and Xuesaitong alone,the curative effect is more significant.It can not only better improve the discomfort symptoms of limb cooling,acid swelling,numbness and intermittent claudication,but also better improve the skin temperature,blood pressure,blood pressure and other symptoms The pulse of dorsalis pedis artery;At the same time,it can more effectively improve the ABI level,blood lipid status,reduce the level of fibrinogen and high-sensitivity C-reactive protein.