Clinical Observation On The Efficacy Of Shuxin Ningji Decoction In Treating Premature Beat

Objective:It provides an objective basis for clinical application to observe the clinical efficacy and safety of Shuxin Ningji Decoction in treating premature beat,which belongs to deficiency of both vital energy and yin and Blood Stasis Syndrome.Methods:60 Patients with mild to moderate were selected,who met the research standards and exclusion criteria.They were divided into the experimental and control groups of 30 people each,according to the three basic principles of contrast,randomization and repetition.These patients were diagnosed as premature beat by Western medicine and palpitation by traditional Chinese medicine,which belongs to Qi and Yin Deficiency Syndrome and Blood Stasis Syndrome.The two groups were treated for four weeks.The control group was treated with metoprolol tartrate tablets,which also known as Beteloc.The medicine was produced by AstraZeneca Pharmaceuticals Ltd and its Chinese medicine quasi-word was H32025391.The medicine was demanded to take orally once 25 mg,two times a day,after breakfast and dinner.The treatment group taking betaloc tablets at the same time was treated with Shuxin Ningji Decoction.The traditional Chinese medicine therapy was taking Shuxin Ningji Decotion,Which was demanded to take orally once 150 ml,two times a day,after breakfast and dinner.Its composition of Shuxin Ningji Decotion was Rhodiola 20 g,Radix pseudostellariae 15 g,Ophiopogon japonicas 15 g,Schisandra chinensis 10 g,Salvia miltiorrhiza 15 g,P.notoginseng 6g,Ligusticum wallichii 10 g,Rhizoma coptidis 6g.The medicine was prepared by the Shanxi Medical University Second Hospital of Chinese medicine preparation room.The clinical indicators were composed of clinical symptom score,the number of premature beat,24-hour ambulatory electrocardiogram,traditional Chinese medicine syndrome.The purpose of statistical analysis of the above indicators was to test the feasibility of clinical application.Results:1.The two groups of patients with types of premature beat,the traditional Chinese medicine symptom score,the number of premature beats before the treatment,the course of disease,age,gender and other general data,the difference was no significant difference.The two groups had comparability.It was believed that the basic situation of the two groups was balanced.2.The two groups of patients with dynamic electrocardiogram were compared and analyzed.The clinical therapeutic effects of the experimental group and the control group were 90.0% and 76.7% with a significant difference(P<0.05).The above results suggested that both groups of treatments can effectively improve the patient's dynamic electrocardiogram,and the experimental group of the treatment was significantly better than the control group's.3.The number of premature beats was compared between the two groups and statistically analyzed.Statistical results showed that the average number of premature beats in the experimental group before and after the treatment was 4741.37 ± 2094.678,2494.67 ± 1994.426,the average number of premature beat in the control group before and after the treatment was 4846.70 ± 2343.675,1248.59 ± 1051.627.The difference had statistical significance in both groups in internal comparison and between the groups(P<0.05).These results suggested that both groups of the treatment can reduce the number of premature beat,the curative effect of the experimental group to control premature beat was better than the control group's.4.The scores of traditional Chinese medicine syndrome were compared between the two groups and statistically analyzed.Statistical results showed that the average score in the experimental group before and after the treatment was 10.13±1.655,3.43±2.542,the average score in the control group before and after the treatment was 9.87±1.520,6.27 ± 3.759.The difference had statistical significance in both groups in internal comparison and between the groups(P < 0.05).The above results suggested that both groups of the treatment can improve traditional Chinese medicine syndrome,and the curative effect of the experimental group was better.5.The total curative effect of traditional Chinese medicine syndrome was compared between the two groups and statistically analyzed.The clinical therapeutic effect was 90.0% in the experimental group and 56.7% in the control group.The difference between the two groups was statistically significant(P < 0.05).The above results suggested that both groups of the treatment can improve traditional Chinese medicine syndrome.The curative effect of the experimental group was significantly better than the control group's.6.Safety observation: No obvious adverse reactions were observed during the clinical observation and the safety indicators were no obvious abnormalities.Conclusion:Taking western medicine betaloc tablets alone can effectively control the onset of premature beat,improve the symptom of patients with palpitations.Traditional Chinese medicine treatment taking Shuxin Ningji Decoction is more conducive to the improvement of efficacy.