Effect Of Different Doses Of Atorvastain On Serum Hs-CRP, APN, Omentin-1 Levels And Major Adverse Cardiac Events After PCI

Objective: Selected patients with coronary heart disease after PCI as the research object.To investigate the effect of different doses of atorvastatin on serum hypersensitive C-reactive protein(hypersensitive C-reactive protein),adiponectin(APN),Omentin-1 levels and the major adverse cardiac events after PCI.So as to better for the prevention of cardiovascular disease and provide theoretical basis for clinical treatment and explore the the ideal doses of atorvastatin for reducing the inflammatory reaction after PCI.Methods:1 From January 1,2015 to January 1,2016,111 patients with coronary heart disease after PCI in Cardiovascular internal medicine,the Tangshan Worker Hospital affiliated to Hebei medical university were chosen,recording its general clinical data such as age,gender,body mass index.Patients were randomly divided into 40 mg high dose A group and 20 mg low dose B group,40 mg high dose group 56 patients,including 30 male and 26 female,among48~74(58.52±11.87)years old,given atorvastatin calcium 40 mg/d.20 mg low dose group 55 patients,including 27 male and 28 female,47~72(58.69±10.25)years old,given atorvastatin calcium 20 mg/d.2 Total cholesterol,triglyceride,low density lipoprotein,adiponectin and Omentin-1 levels of the groups were measured pre-admission,postoperative 3days,3 months after PCI,the adverse drug reactions were followed of 3months and the major adverse cardiac events were observed after 1 year.3 Different times of plasma levels of hypersensitive C-reactive protein(hs-CRP),APN and Omentin-1 levels were examined by ELISA and the differences were compared between two groups.4 Statistical methods: SPSS21.0 software pack was used for statistical analyses.The numerical data was shown as mean±standard deviation(`x±s),non-normal distribution data was expressed in median,t test was used for two group comparison analysis,chi-square test was used for categorical data.P<0.05 was considered as statistic significance.Results:1 The 40 mg high dose group and 20 mg low dose groups of patients' age,sex ratio,body mass index,coronary artery lesions,the number of placing stents and the blood index before pre-admission,there was no statistically significant difference(P>0.05).2 Compared with 40 mg high dose group and 20 mg low dose group,the serum of hs-CRP,APN,Omentin-1 levels pre-admission was no statistically significant difference(P>0.05).3 3 months after PCI,the TC,TG levels of 40 mg high dose group and 20 mg low dose group was more lower than pre-admission(3.66±0.45 mmol/L)vs(4.14 ± 0.46 mmol/L);(1.09 ± 0.30 mmol/L)vs(1.51 ± 0.28 mmol/L),P<0.05,there was statistically significant difference between 40 mg high dose group and 20 mg low dose group(P<0.05).4 3 days,3 months after PCI,the hs-CRP level of 40 mg high dose group and 20 mg low dose group was more lower than pre-admission(P<0.05),there was statistically significant difference;3 days,3 months after PCI,the APN,omentin-1 levels of 40 mg high dose group and 20 mg low dose group was more lower than pre-admission was significantly higher than pre-admission(P<0.05),there was statistically significant difference.3 months after PCI,the hs-CRP level of 40 mg high dose group was significantly more lower than 20 mg low dose group(3.12±0.85 mg/L)vs(4.36±1.22 mg/L),P<0.05,the APN,Omentin-1 levels of 40 mg high dose group was significantly higher than 20 mg high dose group group(14.2±2.55 mg/L)vs(8.78±3.16 mg/L);(28.9±9.59 ng/ml)vs(21.6±6.29 ng/ml),P<0.05.5 Following up for 3 months,we compared the adverse reactions rate of the two groups of patients taking atorvastatin,40 mg high dose group was12.5%,20 mg low dose group was 10.0%,there was no statistically significant difference(P>0.05).The MACE rate of 40 mg high dose group followed-up 1years was 10.7%,20 mg low dose group was 27.3%,the difference had statistical significance(P<0.05),40 mg high dose group was lower than 20 mg low dose group.Conclusion:1 Compared with the patients of taking atorvastatin with 40 mg high dose group and 20 mg low dose group,the 40 mg group,the index of TC,TG,levels and the serum hs-CRP level were more lower than 20 mg group,the APN and Omentin-1 were more higher than 20 mg group.3 months,compared with the adverse reactions rate of the two groups of patients taking atorvastatin,there was no statistically significant difference.While,the MACE rate of the two groups followed-up 1 years,40 mg group was more lower than 20 mg group.2 Atorvastatin can reduce serum hypersensitive C-reactive protein concentration and increase serum adiponectin and omentin-1 concentrations in a dose-dependent manner.40 mg group can alleviate the inflammatory response of PCI,to protect the cardiovascular system.3 40 mg atorvastatin is safe for patients and can protect the cardiovascular system.