Studies On Serum Adiponectin Level In Patients With Coronary Heart Disease And Its Relation To C-Reactive Protein

Objective: To investigate the variation of serum adiponectin in patients with coronary heart disease(CHD) and explore the correlation between the levels of adiponectin and C-reactive protein(CRP). This may help to know the role of adiponectin in the pathogenesis of CHD, the change of the adiponectin may contribute to prevention, diagnosis and therapy in clinic.Methods : Serum adiponectin and CRP were measured by Enzyme-linked Immunosorbent Assay(ELISA) in 60 patients with CHD, and compared with 20 healthy subjects. Fasting plasma glucose(FPG), total cholesterol(TC) and triglyceride (TG) were measured at the same time.Results: Serum concentration of adiponectin in patients with CHD [(5.47 ± 3.08) mg/L ] were significantly lower than in the normals [ (7.14 ± 2.50) mg/L, t = - 2.182, p<0.05 ], and there is a significantly difference between men [ (4.70 ± 2.40) mg/L ] and women patients [ (6.64 ± 3.62) mg/L, t = - 2.142, p<0.05 ] . Serum concentration of adiponectin in patients with AMI were significantly lower than those in patients with OMI [(6.20±2.75) mg/L, t=-2.088, p<0.05 ], SAP [(6.78±3.35 ) mg/L, t=-2.602, p<0.05 ], also serum concentration of adiponectin in patients with UAP [ (4.59 ±3.13 )mg/L, t = - 2. 479, p<0.05 ] were significantly lower than in patients with SAP, there were, however, no significant differences between patients with OMI, SAP and the control group. Serum CRP were significantly elevated in patient with CHD [(5.17± 3.85 )mg/L ]and different significantly compared with control group[ ( 0.64 ± 0.38 )mg/L, t' = 8.959, p<0.001 ], The levels of serum CRP in patients with AMI [ ( 9.00 ± 2.89) mg/L ] were elevated significantly than other groups (t = 3.857-5.879, p<0.001 ) .The levels of serum CRP in patients with UAP [ (5.15 ± 3.42) mg/L ] were significantly higher than in patients with SAP [(3.14 ±2.73) mg/L, t = 2.023, p<0.05.Serum concentrations of adiponectin correlated negatively with FPG (r = -0.309, p<0.05 ), TG (r = - 0.333, p<0.05 ) and CRP ( r = - 0.261, p<0.05 ) . Multiple linear regression showed that TG is independently correlated with the concentration of adiponectin level in patients with CHD.Conclusion: The serum adiponectin levels were significantly decreased in patients with CHD, this decrease may be closely related to the genesis and progress of CHD. The variation of serum adiponectin in patients with CHD reflect the stability of the atherosclerotic lesion.