Retinal Element 1 And The Correlation Of Coronary Atherosclerosis Sex Heart Disease Research

Objective:To analysis relationship of the omentin-1and serum lipids and further explore the relationship between omentin-1and coronary heart disease through determination of level of serum omentin-1and high sensitive C-reactive protein (hs-CRP), to provide the oretical basis for pathogenesis of coronary heart disease.Methods:There were80cases of patients group and52cases of control group from inpatients of cardiovascular hospital of shanxi province in December2010to May2011. Diagnosis of patients with coronary artery disease in patients group consistent with diagnosis standard of WHO on coronary heart disease in1979, and confirmed by coronary angiography:lumen diameter stenosis of at least one vascular of the left anterior descending artery, circumflex and right coronary artery was about more than50%. Among the patients group,56were male,24were female, meanage (58.43±13.34) years old. The control group, patients hospitalized in the same period and coronary angiography negative, and had been exclused of coronary artery disease, among them,32were male,20were female, mean age (56.78±12.89). Using enzyme-linked immunosorbent assay (ELISA) for determination of serum omentin-1and high sensitivity C-reactive protein level. Analysis and compared measurement data with methods of mean±standard deviation, t test, Pearson correlation analysis et al; using SPSS13.0software package to analysis, with statistical significance when P<0.05.Results:Serum omentin-1level of cases from patients group was significantly lower than the control group, the difference was statistically significant (t=3.670, P=0.0090). In patients group, serum omentin-1levels was negatively correlated with cholesterol (CHO)(r=-0.579, P<0.05), low density lipoprotein cholesterol (LDL-C)(r=-0.520, P<0.05), triglyceride (TG)(r=-0.564, P<0.05), load lipoprotein B(apoB)(r=-0.470,P<0.05); and positively correlated with high density lipoprotein cholesterol (HDL-C)(r=0.693,P<0.05), apolipoprotein AI (apoAI)(r=0.501,P<0.05), and had no correlation with hs-CRP(r=0.271,P=0.309).Conclusion:the serum omentin-1may be associated with the occurrence of coronary heart disease, serum omentin-1level may be a good indicator of the evaluation of coronary artery disease risk.We need to confirm it with more large sample cases of control experiments and prospective experiments...