Relationship Between Ischemic Cerebral Infarction With Type 2 Diabetes Mellitus And Its CISS Classification And Blood Lipid

Objective:We divided the patients in our Department of Neurology into five subtypes according to the classification of the Chinese Ischemic Stroke Subclassification(CISS),these patients were all the acute cerebral infarction(ACI)complicated with type 2 diabetes mellitus(T2DM).We have studied statistics of the subtypes of the composition ratio and the relationship between the pathogenesis of different subtypes and different risk factors.At the same time we srudied the correlation between ACI complicated with T2 DM and total cholesterol.Methods:We collected 376 patients of ACI with T2 DM as the sample of observation by CISS classification in First Hospital of Lanzhou University.Choosing 292 cases of acute cerebral infarction,389 cases of healthy subjects,extraction of fasting venous blood test uric acid,Hcy,FIB,TC,TG,HDL,LDL,to analysis of correlation between classification of the CISS and ACI with T2 DM.Results:In the CISS classification,191(50.70%)of Large Artery Atherosclerosis(LAA),103 cases(27.60%)of Undetermined Etiology,Followed by Penetrating Artery Disease(PAD)in 51 cases(13.50%),cardiogenic Stroke(CS)in 30 cases(8.00%),other causes of ischemic stroke(Other Etiology,OE)in 1 case(1.00%).Age,TG,LDL is a risk factor for LAA type(P <0.05).There were no statistically significant differences between the other two subtypes(P> 0.05).There was a "cholesterol paradox" phenomenon in the CS subtypes.Age is a risk factor for CS type.TC is the risk factor of PAD type,the highest proportion of patients with hypertension in PAD type.The risk factor of UE is drinking.There was a significant correlation between the decrease of TC level and the incidence of stroke as well as stroke with 2DM.Conclusion :LAA and UE is the most common types in ACI patients with T2 DM.Different types of ischemic stroke were associated with different risk factors.LDL is associated with LAA.Coronary heart disease is associated with CS.Drinking is associated with UE,TC was a risk factor for PAD,and there were "cholesterol Paradox "phenomenon in CS;the stroke with 2DM has the" cholesterol paradox" phenomenon.