Relationship Between The Level Of Serum 25(OH)D And The Severity Of Acute Cerebral Infarction In Patients With T2DM

Objective:To analyze the relationship between the level of serum25-hydroxyvitamin D[25(OH)D]and the severity of acute cerebral infarction(ACI)in patients with type 2 diabetes mellitus.Methods:We randomly selected 137 patients with type 2 diabetes mellitus(T2DM)in Department of Neuroendocrinology,Second Affiliated Hospital of Hunan Normal University from October 2017 to September2018,which were divided into diabetes mellitus with cerebral infarction group(DCI group)65 cases as experience group,and diabetes without cerebral infarction group(DNCI group)72 cases as control group.According to the National Institute of Health stroke scale(NIHSS)score,patients in DCI group were divided into mild stroke group 38 cases(?4points,CI 1 group)and moderate and severe stroke group 27 cases(>4points,CI 2 group).General data of each group were recorded in detail:ID number,sex,age,course of diabetes,history of coronary heart disease,smoking history,height,weight,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP).All the subjects were collected elbow venous blood on an empty stomach in the morning of the second day of admission to examine the indicators:total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),uric acid(UA),fasting blood glucose(FBG),glycated hemoglobin(HbA1c),25(OH)D.All data are processed by software package SPSS22.0.The measurement data conforming to normal distribution were compared between groups with independent sample t-test,and the comparisons among groups with classified variables were tested with?~2 test.Logistic regression analysis was used to correct the confounding factors and screen the influencing factors of acute cerebral infarction in patients with T2DM.Taking alpha=0.05 as the test level,P<0.05 as the difference has statistical significance,P<0.01 as the difference has statistical significance.Results:1.The level of serum 25(OH)D in DCI group was significantly lower than that in DNCI group(P<0.01).2.The level of serum 25(OH)D in CI 2 group was lower than that in CI 1 group(P<0.05).3.The serum 25(OH)D deficiency rate in CI 2 group was higher than that in CI 1 group(?~2=5.41;P<0.05).4.The systolic blood pressure and UA level in DCI group was significantly higher than that in DNCI group(P<0.01);the levels of LDL-C and HbA1c in DCI group were higher than those in DNCI group(P<0.05);there was no difference in the remaining indexes(P>0.05).5.The systolic blood pressure and the levels of LDL-C and UA in CI2 group was higher than that in CI 1 group(P<0.05);there was no difference in other indicators(P>0.05).6.Logistic regression analysis showed that SBP(beta=0.303,P=0.011),UA(beta=0.007,P=0.010),25(OH)D(beta=-0.107,P=0.008)were independent influencing factors of acute cerebral infarction in patients with T2DM.Conclusions:1.The serum level of 25(OH)D was decreased in patients with T2DM and ACI,and the level of 25(OH)D was correlated with the severity of cerebral infarction.2.The levels of SBP and UA were correlated with the severity of cerebral infarction in patients with T2DM.3.The serum level of LDL-C and HbA1c were increased in patients with T2DM and ACI.