The Influence Of Parecoxib Or Dezocine Combine With Ropivacaine On The Pain After Mammary Cancer Surgery

Objective: To investigate the influences of intravenous parecoxib sodium or dezocine combine with ropivacaine local infiltration anesthesia on the pain after mammary cancer.Methods: In this study,we divided 100 breast cancer patients aged 30-65,ASA I or II,into 4 groups(n=25): control group(Group N),ropivacaine group(Group P),parecoxib combine with ropivacaine group(Group PL)and dezocine combine with ropivacaine group(Group DL).In group PL and DL were injected parecoxib sodium 0.8 mg/kg or dezocine 0.1 mg/kg at fifteen minutes before incision.The patients in group L,group PL and group DL were treated with local infiltration anesthesia by 0.375% ropivacaine in the ending of surgery.We did not give any special treatment on the patients in group N.We used visual analogue scale(VAS score)to evaluate the degree of postoperative pain at 2 h,4 h,8 h,12 h,24 h and 48 h after operations.We also recorded the additional requirement of analgesic drugs and adverse reactions such as dizziness,nausea,vomiting and respiratory inhibition in 48 hours afteroperations.Results: We did not find significant difference of age,weight,height,operative type,anesthesia time,operation time extubation time,the additional requirement of analgesic drugs and adverse reactions among four groups(P>0.05).Compared with group N,the VAS score of group L were lower at each point within 12 hours after operation(P<0.05).Compared with group N the VAS score of group PL and DL were significantly lower at each point within 48 hours after operation(P <0.05).The VAS score of group PL at each point(except 12 h)were lower than group L(P<0.05)while the pain score of patients in group DL at each point were lower than group L(P<0.05).The pain score of patients among group PL and DL were found no difference(P>0.05).Conclusion: The intravenous parecoxib sodium or dezocine combine with ropivacaine local infiltration anesthesia on the patients suffered radical postmastectomy pain is a good perioperative pain management program.