| Ojective To compare and analyse the analgesic efficacy of parecoxib sodium and ropivacaine after gynecological laparoscopic surgery.Methods A total of 120 patients scheduled for gynecological laparoscopic surgery in the Affiliated Hospital of YanBian university during 2015.12 to 2016.6 were randomly allocated to the parecoxib sodium group(group P,n=30),the ropivacaine(group R,n=30),parecoxib in conbination with ropivacaine group(group PR,n=30)and the control group(group C,n=30).Patients in the group P received parecoxib sodium 40mg intravenously half an hour before the end of operation,Patients in the group R were administered intraperitoneally after pneumoperitoneum was achived and before the end of operation,and injected subcutaneously 0.66%Ropivacaine 10ml after the end of surgery.Patients in the group PR received the same clinical intervetion to group P and group R,while patients of group C didn’t receive any clinical intervention.All patients recerved PCA.Scores of visual analog scale(VAS),Ramsay scale(RS),and bruggrmann comfort scale(BCS),the incidence of untoward effect was recorded at 1h,3h,6h,12h,and 24h after the end of operation.Results Postoperative data recorded at each time showed,Group P,group R and group PR had lower VAS scorings than Group C obviously at each time point,and Group PR had lower scorings than Group R at 6h after the end of operation;Group P,Group R,Group PR had more appropriate Ramsay scales at 1h after the end of operation;Group P,Group R,Group PR had higher BCS scorings than Group C at 1h and 6h after the end of poeration,Group P had higher BCS scorings than Group PR at 12h and 24h after the end of operation;group P,group R,group PR had less pressing number of PCA than group C at each time point,and group PR had less pressing number of PCA than group P at lh,3h,6h,12h after end of operation,and group PR had less pressing number of PCA than group R at 6h after end of operation,group P,group R,group PR had less cumulated dosage of fentanyl at each time point,and group PR had less cumulated dosage of fentanyl at 1h and 3h after end of operation,group PR had less cumulated dosage of fentanyl at 3h after end of operation,group P,group R,group PR had less incidence of adverse reaction than group C,every test result was statistically significant(P<0.001).Conclusion Intravenous injection of parecoxib sodium,intraperitoneal and subcutaneous injection of ropivacaine can both obviously reduce postoperative fentanyl consumption and adverse reaction,and effectively alleviate postoperative pain of gynecologic laparoscopic surgery. |
