Changes Of Serum Homocysteine In Patients With Type 2 Diabetes Mellitus Complicated With Hypertension And Its Causes

Objective: The aim of this study was to investigate the changes in serum homocysteine levels in patients with type 2 diabetes mellitus complicated with hypertension and its possible causes.Methods: A total of 158 patients with type 2 diabetes mellitus were enrolled in our hospital from January 2016 to December 2016.Among them,85 patients with type 2 diabetes mellitus complicated with hypertension were regarded as diabetic and hypertensive group,73 patients with type 2 diabetes without hypertension were regarded as diabetic group.32 healthy subjects in the same period from the physical examination center were regarded as a normal control group.All selected subjects meet the diagnostic criteria and exclusion criteria.Clinical data were collected for all subjects.General biochemical indicators and serum homocysteine(Hcy),folic acid,vitamin B12(VitB12),fasting insulin(FINS)were also tested.Then the diabetic and hypertensive group were divided into homocysteine-increased group(Hcy elevated group)and homocysteine normal group(Hcy normal group),according to whether the serum Hcy greater than or equal to 15?mol / L.Results: The level of Hcy in diabetic and hypertensive group was higher than that in diabetic group and normal control group,the difference was statistically significant(P <0.05).The level of folic acid was lower than that of diabetes mellitus group and normal control group,the difference was statistically significant(P <0.05).The level of folic acid in Hcy elevated group was significantly lower than that in Hcy normal group(P <0.05).Correlation analysis showed that serum Hcy levels were positively correlated with creatinine(Cr)and urea nitrogen(BUN)in patients with type 2 diabetes mellitus complicated with hypertension and were negatively correlated with folic acid,the difference was statistically significant(P <0.05).However,there was no significant Linear correlation between Hcy and age,height,body weight,BMI,systolic blood pressure,diastolic blood pressure,fasting blood glucose,postprandial blood glucose,glycosylated hemoglobin,ALT,AST,UA,TG,Vit B12,HOMA-IR(P> 0.05).Conclusion: Serum elevated levels of Hcy in patients with type 2 diabetes mellitus complicated with hypertension may be due to the decrease of folic acid level.