The Clinical Reserch Of Effect Of Changyu Enema Formula On Serum Antibody In Patients With Ulcerative Colitis(Rectal Type)

Objective To observe the effects of Changyu Enema Formula in the treatment of Damp-Heat syndrome of ulcerative colitis(rectal type)and the influence of serum antibody(PANCA,GAB,ASCA and PAB)on the positive rate,explore the mechanism of Changyu Enema Formula on Damp-Heat syndrome of ulcerative colitis(rectal type),so as to provide a reliable theoretical basis for the further popularization and application of Changyu Enema Formula in clinical practice.Methods 60 patients who meet the criteria of outpatient and inpatient from January 2015 to October 2016 were selected as the subjects and randomly divided into treatment group and control group,with 30 patients per group.The treatment group was treated with Changyu Enema Formula to retention enema,and the control group was given Mesalazine to the anus for 8 weeks.TCM symptom score,electronic colonoscopy image score,modified Mayo score,the positive rates of serum PANCA,ASCA,PAB and GAB were observed before and after treatment.The data were processed by SPSS17.0 statistical software.Results(1).After treatment,comparison of the TCM symptom scores between two groups with those before the treatment respectively.The difference has statistically significant and enjoy comparability(P<0.01).Comparison of the TCM symptom scores between two groups after treatment,treatment group is more superior than control(P<0.01).(2).After treatment,the modified Mayo scores of the two groups were compared with those before the treatment respectively.The difference has statistical meaning(P<0.01).Comparing the Mayo scores of the two group after treatment,treatment group is more superior than control(P<0.01).(3).After treatment,comparison of the IBDQ scales between two groups with those before the treatment respectively.The difference has statistically significant and enjoy comparability(P<0.01).Comparing the two groups after treatment,treatment group is more superior than control(P<0.01).(4).After treatment,comparison of the electronic colonoscopy image scores between two groups before the treatment respectively and the difference has statistically significantand enjoy comparability(P<0.01).Comparison of electronic colonoscopy image scores between two groups after treatment,the difference has statistically significant and enjoy comparability(P<0.05).(5).After treatment,comparison of the positive rates of PANCA between two groups was apparently lower than those before treatment.comparison of the PANCA between two groups after treatment,the difference has statistically significant and enjoy comparability(P<0.05).(6).After treatment,comparison of the positive rates of GAB between two groups was lower than those before treatment.But there was no statistical meaning between the GAB differences of the two groups after treatment(P>0.05).(7).After treatment,comparison of the positive rates of ASCA between two groups was not differences with before treatment,There was no statistical meaning between the ASCA differences of the two groups after treatment(P>0.05).(8).After treatment,comparison of the positive rates of PAB between two groups was not differences with before treatment,There was no statistical meaning between the PAB differences of the two groups after treatment(P>0.05).(9).After treatment,comparing the clinical efficacy of the two groups of patients,treatment group is more superior than control(P<0.05).(10).No adverse reactions in treatment group,the control group found that one cases of rash after treatmentConclusion The treatment group was superior to the control group in terms of TCM symptom score,modified Mayo score,IBDQ scale,colonoscopy mucosal image score,serum antibody PANCA,GAB;the efficacy of Changyu Enema Formula on Damp-Heat syndrome of ulcerative colitis is accurate.