| Objective: In this study,the retention enema of Changyu enema combined with umbilical application of Chinese medicine was used to treat mild to moderate ulcerative colitis of damp heat of the large intestine during the active period,and compared with mesalazine retention enema alone and retention enema treatment of Changyu enema alone.Analyze the effects of three different therapies on the observation indicators of mild to moderate colorectal damp-heat type UC during the active period,and compare the therapeutic effects of the three different therapies,and provide more new theories for the clinical development and promotion of TCM treatment of UC in accordance with.Methods:From October 2019 to October 2020,UC patients in the Anorectal Department of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were selected.90 patients who met the requirements of this study were selected and randomized according to the method of statistical randomization.The patients were divided into a western medicine control group,a Chinese medicine control group,and an enema formula + umbilical application group(abbreviation: Chinese medicine intervention group),with 30 cases in each group.The western medicine control group received mesalazine retention enema treatment,the traditional Chinese medicine control group received Changyu enema retention enema treatment,and the Chinese medicine intervention group was combined with traditional Chinese medicine umbilical treatment based on the treatment of the traditional Chinese medicine control group.The total treatment course was 30 days.Observation And statistically analyze the modified Mayo score,TCM syndrome score,serum ESR and CRP content changes,Baron endoscopic m UCosal score and Geboes index score changes in the three groups of patients before and after treatment,and compare the effective rates of TCM syndromes in the three groups after treatment.The difference between the effective rate and the comprehensive clinical efficacy is used to comprehensively determine the clinical efficacy.Results:1.Baseline comparison: There was no statistically significant difference in age,gender,course of disease,severity of illness,Modified Mayo Scores,TCM Syndrome Scores,changes ESR and CRP levels in Serum,Baron Endoscopic MUCosal Scores,and Geboes Index Scores before treatment among the three groups of patients.(P>0.05),comparable.2.Intra-group comparison: After treatment,the Modified Mayo Scores,TCM Syndrome Scores,changes ESR and CRP levels in Serum,Baron Endoscopic MUCosal Scores,and Geboes Index Scores of the three groups of patients decreased compared with before treatment,and the differences were statistically significant.(P<0.05).3.Comparison between groups:(1)After treatment,the modified Mayo score,TCM syndrome score,serum ESR and CRP content changes,Baron endoscopic m UCosal score and Geboes index score data of the western medicine control group were compared with those of the two traditional Chinese medicine groups,and the results were significantly different(P<0.05);After treatment,the modified Mayo score,TCM syndrome score,serum ESR and CRP content changes and Geboes index score data in the traditional Chinese medicine control group were compared with the traditional Chinese medicine intervention group,and the differences were statistically significant(P<0.05);After treatment,the Baron endoscopic m UCosal score of the Chinese medicine intervention group was compared with that of the Chinese medicine intervention group,and the difference was not statistically significant(P>0.05).(2)After treatment,the efficacy of traditional Chinese medicine syndromes in the three groups of patients was compared.The effective rate of the western medicine control group was 80.00%,the effective rate of the traditional Chinese medicine control group was 90.00%,and the effective rate of the traditional Chinese medicine intervention group was 96.67%.The traditional Chinese medicine intervention group was compared with the two control groups.All were statistically significant(P<0.05);after treatment,the clinical comprehensive efficacy of the three groups was compared.The effective rate of the western medicine control group was 80.00%,the effective rate of the traditional Chinese medicine control group was 90.00%,and the effective rate of the traditional Chinese medicine intervention group was 93.33%.Compared with the two control groups,the differences were statistically significant(P<0.05).(3)There were no obvious abnormalities in blood routine,Urine routine,liver and kidney function and related vital signs of the three groups of patients before and after treatment,and no adverse reactions occurred.The three treatment methods have good safety.Conclusions:Changyu Enema Retention Enema combined with traditional Chinese medicine application to treat mild to moderate colorectal damp-heat UC during the active period,with definite curative effect,can effectively relieve the clinical symptoms of patients,improve TCM syndromes,red UCe ESR,CRP inflammation indicators,and red UCe intestinal tissue inflammatory cell infiltration,It promotes the healing and repair of the intestinal m UCosa,and its curative effect is better than that of Mesalazine Retention Enema and Simple Changyu Enema Retention Enema.It is safe and worthy of clinical promotion. |
