Polymorphism Distribution Of Rs316019 Of SLC22A2 In The Uygur Population Of Xinjiang

Objective: To study the polymorphism distribution of SLC22A2 gene rs316019 loci in Uygur of Xinjiang,and analysed the racial differences in different populations,and further to provide a genetic basis for further study the Metformin's Pharmacogenetics in Uygur of this region.Methods: The genotypes of rs316019 loci(G808T,A270S)in 276 unrelated healthy Uygur male were detected by the techniques of SNaP shot,and the genotype and allele frequency,the data from NCBI gene pool and the related articles,were subsequently compared with different populations,and analysed the racial differences in their distribution.Results: The genotypes distribution of rs316019 loci was in the Hardy-Weinberg equilibrium(P>0.05).the frequencies of genotypes(CC,CA,AA)were 79.7%,18.1% and 2.2% in Xinjiang Uygur,the frequency of minor allele A was 11.2%,we did not find the allele G or T.It's polymorphism distribution showed significant differences between Xinjiang Uygur and the Han,the African,the American and European populations etc.(P<0.05).Conclusion :There was national difference in polymorphism of SLC22A2 rs316019 loci among different populations,and maybe it will bring the difference about drugs' pharmacogenetics and related diseases' development etc.accordingly.