| Purpose:Observe the Kidney detoxification soup combined with Shenkang Suppository for the treatment of CKD 3-5 of the clinical curative effect,clinical treatment of non dialysis patients with CKD in order to provide an effective treatment and solution.Methods:By consulting chinese and western medicine treatment of CKD literatures,summarizing tutor method and experience of treatment of CKD,used oral kidney detoxification soup combining with Shenkang Suppository into anus as treatment options.Collected 75 cases of patients without dialysis CKD3-5,according to the proportion of 2:1:2 were randomly divided into treatment group,control group 1 and group 2,giving treatment group foundation treatment kidney detoxification soup and Shenkang Suppository,control group 1 foundation treatment and kidney detoxification soup,control group 2 foundation treatment and syndrome differentiation soup.Use both before and after the treatment of symptom integral and laboratory indexes to evaluate and analyze curative effect.Result:1.Traditional Chinese medicine syndrome integral:Control group 1 before treatment of integral is(9.07±5.13),after treatment of integral is(5.93±3.35),control group 2 before treatment of integral is(11.87±3.76),after treatment of integral is(9.87±4.42).Treatment group before treatment of integral is(11.47±6.95),after treatment of integral is(5.80±4.2),three groups both before and after the treatment,have significant statistical difference(P<0.01).2.Renal function indices:(1)Control group 1 before treatment of Scr was(340.47± 128.62)?mol/L,after treatment of Scr was(274.63 ±123.22)?mol/L,P<0.01.Treatment group before treatment of Scr was(342.95± 168.22)?mol/L,after treatment of Scr was(261.82± 116.61)? mol/L,P<0.01,meaned the Scr level of treatment group and control group 1 dropping obviously,Control group 2 before treatment of Scr was(342.77± 164.00)?mol/L,after treatment of Scr was(298.83 ± 164.28)? mol/L.Treatment group before treatment of eGFR was(21.82±13.93)ml/min,after treatment of eGFR was(29.19± 17.52)ml/min,P<0.01,meaned the Scr level of treatment group rising obviously.Control group 1 before treatment of eGFR was(24.18± 13.79)ml/min,after treatment of eGFR was(30.27±19.69)ml/min,P<0.05.Control group 2 before treatment of eGFR was(23.28±15.31)ml/min,after treatment of eGFR was(25.55±19.49)ml/min,P>0.05.(2)CKD3,Treatment group before treatment of Scr was(171.51±41.00)?mol/L and after treatment was(140.91 ±28.71)?mol/L,P<0.01.Control group 1 before treatment of Scr was(151.40±49.69)?mol/L and after treatment was(121.26±23.21)?mol/L,P>0.05.Control group 2 before treatment of Scr was(169.13±22.56)p,mol/L and after treatment was(140.26±46.80)?mol/L,P>0.05.Treatment group CKD3 in dropping the Scr was better than control group 2(P<0.05).CKD4,Treatment group before treatment of Scr was(294.59±59.04)?mol/L and after treatment was(247.08±72.25)?mol/L,P<0.01.Control group 1 before treatment of Scr was(285.20±60.09)?mol/L and after treatment was(240.78±77.07)?mol/L,P<0.01.Control group 2 before treatment of Scr was(279.83±98.39)?mol/L and after treatment was(246.79±66.70)?mol/L,P>0.05.Treatment group CKD4 in dropping the Scr was better than control groups 2(P<0.05).CKD5,Treatment group before treatment of Scr was(497.57±145.25)?mol/L and after treatment was(354.73±103.97)?mol/L,P<0.01.Control group 1 before treatment of Scr was(469.88±157.41)?mol/L and after treatment was(398.33 ± 137.14)?mol/L,P>0.05.Control group 2 before treatment of Scr was(470.12±154.81)?mol/L and after treatment was(453.22±115.51)?mol/L,P>0.05.Treatment group CKD4 in dropping the Scr was better than control groups(P<0.01).CKD3,Treatment group before treatment of eGFR was(40.88±10.74)ml/min and after treatment was(51.19±11.79)ml/min,P<0.01.Control group 1 before treatment of eGFR was(40.51±8.45)ml/min and after treatment was(48.40±14.05)ml/min,P>0.05.Control group 2 before treatment of eGFR was(44.44±10.82)ml/min and after treatment was(48.51±21.04)ml/min,P>0.05.Treatment group CKD3 in rising the eGFR was not better than control groups(P>0.05).CKD4,Treatment group before treatment of eGFR was(20.41±4.91)ml/min and after treatment was(27.491±13.18)ml/min,P<0.01.Control group 1 before treatment of eGFR was(23.09 ± 3.37)ml/min and after treatment was(26.38 ±13.98)ml/min,P>0.05.Control group 2 before treatment of eGFR was(23.26±4.07)ml/min and after treatment was(27.61±7.41)ml/min,P>0.05.Treatment group CKD4 in rising the eGFR was better than two control groups(P<0.05).CKD5,Treatment group before treatment of eGFR was(10.30±2.75)ml/min and after treatment was(15.97±5.78)ml/min,P<0.01.Control group 1 before treatment of eGFR was(11.31±1.33)ml/min and after treatment was(11.08 ±3.07)ml/min,P>0.05.Control group 2 before treatment of eGFR was(10.28±2.40)ml/min and after treatment was(10.01±2.61)ml/min,P>0.05.Treatment group CKD5 in rising the eGFR was better than control groups obviously(P>0.05).3.The clinical total effective rate:Treatment group was 96.67%,control group 1 total effective rate was 93.33%,and control group 2 was 80.00%.The total effective rate of treatment group was better significantly.Made chi-square test between treatment group and control group 1 and had difference,P=0.048,meaning that treatment group curative effect was better than control group2.Made chi-square test between treatment group and control group 2 and had difference,P=0.003,meaning that treatment group curative effect is better than control group 2.Conclusion:Using the Kidney detoxification soup combined with Shenkang Suppository treatments for CKD3?5 is better than traditional treatment,significantly improving symptoms,improving patient quality of life,patients with stable or even lowering Scr levels,delaying the progress of renal function,is worth further research to explore. |
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