Clinical Efficiency Observation On Treatment Of Hashimoto's Thyroiditis With Hypothyroidism By "Xiaoying Decoction"

Objective:To observe the clinical efficacy of "Qishao Xiaoying Decoction" in the treatment of Hashimoto's thyroiditis with hypothyroidism,and to explore whether the "Qishao Xiaoying Decoction" can cooperate with western medicine,adjust the thyroid hormone recovery earlier and faster Normal levels,and focus on the unique advantages of traditional Chinese medicine in reducing thyroid-related antibodies such as TGAb,TPOAb levels.Method:Forty patients with Hashimoto's thyroiditis complicated with hypothyroidism were randomly divided into two groups.The treatment group was treated with traditional Chinese medicine "Qishao Xiaoying Decoction" combined with L-thyroxine sodium tablets.The control group was treated with L-thyroxine sodium tablets,Taking 4 weeks for a course of treatment,a total of three courses of treatment.(TSH,FT3,FT4)and thyroid-associated antibodies(TPOAb,TGAb)before and after treatment were observed,and the clinical adverse events and the compliance status of the patients were observed before and after treatment.The changes of symptoms and signs were observed before and after treatment.Result:There was no statistically significant difference between the two groups in terms of age,sex and course of disease before treatment,indicating that the two groups were comparable.1.In the level of thyroid hormone:After 4 weeks of treatment,TSH in the treatment group was significantly lower than that before treatment(P<0.05),while there was no significant difference in the control group.After 8 weeks of treatment,the TSH level in the control group was significantly higher than that before treatment(P<0.01 or P<0.05).There was significant difference between the two groups(P<0.05).There was significant difference(P<0.01 or P<0.05)between the two groups at 4 weeks,8 weeks and 12 weeks after treatment.After 4 weeks,the level of FT3 in the control group was higher than that before treatment(P<0.05).The level of FT3in the control group was significantly higher than that in the control group(P<0.05)There was significant difference between the two groups(P<0.05)in the treatment group compared with the control group at 8 weeks and 12 weeks after treatment.(P<0.05).The level of FT4 in the control group was higher than that in the control group(P<0.01).The level of FT4 in the control group was significantly higher than that in the control group(P<0.05)There was significant difference between the two groups(P<0.01)in the treatment group compared with the control group at 8 weeks and 12 weeks after treatment.2.Thyroid-related antibody levels:After treatment for 8 weeks,TGAb in the treatment group was significantly lower than that before treatment(P<0.05),while no significant difference was found in the control group before and after treatment;TGAb in the treatment group after 12 weeks Compared with the control group,there was significant difference(P<0.05).After treatment for 12 weeks,TPOAb in the treatment group was significantly lower than that before treatment(P<0.05),while there was no significant difference between the two groups before and after treatment.Compared with the control group,There was significant difference(P<0.05)3.In the TCM syndrome score,there was a significant difference(P<0.01 or P<0.05)in the treatment group before 12 weeks of exacerbation,fatigue,fatigue,depression and less appetite(P<0.01 or P<0.05),there was no significant change in the neck before swelling and less appetite.Compared with the control group,there was no significant difference between the two groups(P<0.01 or P<0.05)There were significant differences(P<0.01 or P<0.05)in the treatment group before the neck swelling,fatigue fatigue,depression,4.In the treatment group,the total effective rate was 73.68%after treatment in the treatment group.The total effective rate of the control group was 44.44%.There was significant difference between the two groups(P<0.01)5.The total effective rate was 73.68%in the treatment group and 38.89%in the control group.There was significant difference between the two groups(P<0.01)6.The treatment group and the control group have a good safety,medication 3 course of treatment were no significant adverse reactions and side effects Conclusion:"Qishao Xiaoying Decoction" can cooperate with western medicine(L-thyroxine sodium tablets),earlier and faster regulation of thyroid hormone to return to normal levels,and can play the advantages of traditional Chinese medicine significantly improved symptoms and signs,significantly reduced thyroid-associated antibodies Such as TGAb,TPOAb levels,and the efficacy of stability,no obvious side effects.