Prevalence And Risk Factors Of Infertility In Women Of Childbearing Age In Zhejiang Province

Objective:To explore the prevalence of infertility and its risk factors in reproductive women in Zhejiang Province.Methods:We randomly recruited 1953 reproductive women aged 20 to 45 in our cross-sectional study during 9/2014-12/2015 from 10 regions of Zhejiang Province.A questionnaire survey?physical examination?gynecological examination?transvaginal B ultrasound were applied in this study.Women who fail to achieve a successful pregnancy after 12 months or more of regular unprotected intercourse were diagnosed as infertility,which is based on American Society for Reproductive Medicine(ASRM).(x±s)was applied to described the measurement data,t test was used to analyse the measurement data,and count data were described by ratio and 95%confidence interval(95%CI)and the binary data were analysed by chi-square test;also,logistic regression was applied in multiple factors analysis.P<0.05 was defined as statistically significance.Results:1.There were 1953 valid questionnaires,in which 93 women were diagnosed as infertility.The total morbidity of infertility was 4.76%.In these infertility women,the ratio of the primary and secondary infertility was 22.6%(21/93)and 77.4%(72/93)respectively.2.The cause of infertility in Zhejiang Province included the following reasons:tubal factor26.9%(25/93),ovulation dysfunction 24.7%(23/93),uterus factor8.6%(8/93),endometriosis 5.4%(5/93),tubal combined with ovulation dysfunction 2.2%(2/93),male factors 2.2%(2/93),and 11.8%(11/93)infertility women didn't find exact reasons.Also,18.3%(17/93)of the infertility women didn't have pregnacy plan.3.According to the marriage age,the infertility incidence is 10.3%in age of ?30,which is significantly higher than 3.2%in age of<24(P<0.05)and 5.8%in age of 25-29?4.Univariate analysis indicated that the elder marriage age,the younger menarche age,urban household registration,highly educated,mental workers,irregular menstruation,oligomenorrhea,hypomenorrhea<5ml),mycoplasma infection,overweight(BMI?25)were the risk factors for female infertility(All P<0.05).5.Multiple-factor analysis and Logistic regression analysis showed that the elder marriage age,the younger menarche age,irregular menstruation,hypomenorrhea,mycoplasma infection,overweight(BMI?25)were the dependent risk factors for female infertility(All P<0.05).Conclusion:1.The incidence of infertility is 4.76%in Zhejiang Province.2.Tubal factor and ovulation dysfunction were the main cause of female infertility in Zhejiang Province.3.The elder marriage age,the younger menarche age,irregular menstruation,hypomenorrhea,mycoplasma infection,overweight(BMI>25)were dependent risk factors in female infertility.4.Appropriate marriage age and pregnancy plan should be advocated,when there isa irregular menstruation and overweight should be alerted,and a detailed pre-pregnancy physical examination is necessary.