Clinical Observation On The Effect Of Jiawei Sangbaipitang On AECOPD In Treating Phlegm And Blood Stasis Syndrome And Its Effect On MMP-9,NE And D-dimer

Objective:To observe the clinical effect of Jiawei Sangbaipitang in treating patients wit h acute exacerbation of chronic obstructive pulmonary disease with phlegm and blood stasis syndrome and the effect on serum MMP-9,NE and D-dimer,and provide the b asis for the further application of Chinese medicine in the treatment of patients with a cute exacerbation of chronic obstructive pulmonary disease.Methods:70 patients matching the inclusion of this research criteria with acute exacerb ation of chronic obstructive pulmonary disease(COPD)were randomly divided into co ntrol group(35 cases)and treatment group(35 cases).The control group according to GOLD guidelines combined with the patient's condition using Western medicine,the t reatment group used traditional Chinese medicine Jiawei Sangbaipitang based on the a ddition of the treatment of the control group,treatment for 2 weeks.Record Analysis:general information(gender,age,BMI,smoking),pulmonary function(FEV1%(1 sec ond forced expiratory volume in percent predicted),MMP-9(matrix metalloproteinase 9),NE(neutrophil elastase),D-dimer(fibrinolytic specific degradation products)and ot her data.All subjects took fasting venous blood before 8:00 a.m.The levels of serum MMP-9,NE and plasma D-dimer were measured by enzyme-linked immunosorbent as say(ELISA).The difference between the control group and the treatment group was a nalyzed before and after treatment,and MMP-9,NE,D-dimer were analyzed.Results:1.Clinical efficacy of traditional Chinese medicine:This topic observation sho wed that,the total effective rate of treatment group was 91.42%,the total effective ra-te of control group was 85.71%,the treatment group was superior to the control grou-p,the difference was significant,P<0.05.2.TCM syndrome total points and individual symptoms,signs points:The total s-core,cough,sputum,wheezing,lung rales,individual symptoms and signs before and after treatment were statistically analyzed,with statistical differences,P<0.05.Analyzin g the data between the two groups after the treatment and the comparison between th e difference between the two groups,the treatment group was better than the control g roup,with significant difference,P<0.05.3.There was no significant difference in FEV1%,MMP-9,NE and D-dimer betwee n the two groups before treatment,P>0.05,comparable.There were significant differenc es in FEV1%,D-dimer,MMP-9 and NE in treatment group before and after treatment,P<0.05.There were significant differences in FEV1%,MMP-9,NE and D-dimer in control group before and after treatment,P<0.05.Compared with the control group,the level o f FEV1%in the treatment group was higher than that in the control group,but there w as no significant difference between the two groups(P>0.05),the levels of MMP-9,N E and D-dimer in the treatment group were significantly higher than those in the cont rol group(P<0.05).By comparing the difference of two groups,the levels of FEV1%,MMP-9,NE and D-dimer in the treatment group were better than those in the control group,the difference was statistically significant(P<0.05).4.MMP-9 and the indicators of a simple correlation analysis:negatively correlate d with FEV1%(r =-0.678,P = 0.000),and NE(r=0.610,P=0.000)D-dimer(r = 0.587,P = 0.000),smoking(r = 0.326,P = 0.000),BMI(r = 0.694,P = 0.000)was positively correlated.5.NE and the indicators of a simple correlation analysis:negatively correlated wi th FEV1%(r =-0.622,P = 0.000),and positively correlated with MMP-9(r = 0.610,P = 0.000),D-dimer(r = 0.856,P = 0.000)and BMI(r = 0.692,P = 0.000).6.D-dimer and the indicators of a simPle correlation analysis:negatively correlate d with FEV1%(r =-0.626,P = 0.000),and positively correlated with MMP-9(r = 0.587,P = 0.000),NE(r = 0.856,P = 0.000),the age(r = 0.180,P = 0.034),BM I(r = 0.590,P = 0.000).Conclusion:(1)The decreased lung function sputum of blood stasis syndrome in patie nts with acute exacerbation of chronic obstructive pulmonary disease is closely related to the increasing of MMP-9,NE,D-dimer.(2)Jiawei Sangbaipitang flavored treatment of patients with acute exacerbation of chronic obstructive pulmonary disease with phlegm and blood stasis syndrome,effectiv ely slowed the clinical symptoms and reduced the levels of MMP-9,NE,D-dimer.