Clinical Observation Of Activating Blood Circulation And Resolving Phlegm Therapy For AECOPD With Phlegm-Stasis Syndrome And Its Effect On Hemorheology And D-dimer

Objective:To observe the promoting blood circulation and removing blood stasis method for chronic obstructive pulmonary disease in patients with acute aggravating period of phlegm heat exchange by the symptoms,physical signs,pulmonary function,blood rheology and D-dimer. evaluate the effects of promoting blood circulation and removing blood stasis method in the treatment of chronic obstructive pulmonary disease with acute aggravating period of application value.provide more basis for the clinical application of promoting blood circulation and removing blood stasis method and trying to preliminary explore the blood rheology and D-dimer in acute aggravating period of copd application value.Method:Select 56 cases in accordance with the inclusion criteria in the Sichuan province Chinese medicine hospital respiratory patients with chronic obstructive pulmonary disease in the hospital from June 2014 to October 2015.Randomly divided into experimental group (n=28) and control group (n=28).Experimental group and control group with conventional western medicine treatment, while the experimental group used the method of promoting blood circulation and removing blood stasis which based on Tinglidazaoxiefeitang and Guizhifulingwan additionally, course of treatment for 14 days,before and after treatment in the integral a symptoms and physical signs pulmonary function test, blood rheology and compare the two groups before and after treatment in patients with symptoms and physical signs integral part, pulmonary function, blood rheology indexes and D-dimer.Result:1.The experimental group terminated in 2 cases,the control group fall off in 1 case,the rest of the49 patients were successfully completed. The experimental group and control group before treatment in gender,age,disease symptoms and physical signs of integral and the laboratory indexes had no difference (P<0.05),comparable.2.Two groups of curative effect,effective rate was 92.0%, while the control effectiveness 87.5%,comparison between the two groups(P<0.05),has the difference.the experimental group is better than the control group.3.The experimental group and the control group before and after the treatment of symptoms and physical signs of integral significant differences(P<0.05).the two groups of patients with symptoms and physical signs of integral were improved;Compared with the control group.experimental group after treatment symptoms and physical signs of integral have significant differences.prompt the experimental group is better than the control group.4.In the two groups after treatment in patients with FEV1% account of the expected value.FEV1/FVC than before treatment were significantly different(P<0.05),shows that the two groups after treatment in patients with pulmonary function were improved:Compared with the control group.experimental group after treatment in patients with FEV1% account for of the expected value.FEV1/FVC have significant differences.which shows that experimental group is better than the control group.5.Two groups of patients after treatment the whole blood viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte rigidity index, erythrocyte deformation index TK and plasma fibrinogen were significantly different than before treatment (P <0.05).while the red blood cells deposited without difference (P>0.05),and the experimental group in the improvement of whole blood viscosity, plasma viscosity, erythrocyte aggregation index, erythrocyte rigidity index, erythrocyte deformation index TK and plasma fibrinogen is more obvious.Conclusion:The method of promoting blood circulation and removing blood stasis in the treatment of COPD acute aggravating period which belongs phlegm heat knot each certificate can significantly improve symptoms.improve pulmonary function.influence blood rheology and D-dimer.while it is not obvious to improve lung function.