The Research Of JM No.1 Wenyang Separated Decoction Influence To The Related Indicators Of The Experimental Arteriosclerosis Obliterans

Objective: Using peripheral vascular disease clinical Chinese medicine effective party----JM No.1,to study its Wenyang separated decoction with experiments on animals;observe the effects of this separated decoction on treating ASO,discusse the mechanism of wenyang For the prevention and treatment of an experimental ASO;carry out TCM thepreliminary study of the ASO yang-deficiency syndrome model.Methods: Choose 30 New Zealand white rabbits,According to the principle of randomized,divided those rabbits into 5 groups:normal control group,model group JM No.1 decoction,JM No.1 Wenyang demolition parties and Jinkui Shenqi pill group,6/group.Feeding model normal group with normal diet,feed the rest of the four groups with high--fat diet100g/d.After the success of the preparation of model,accordi-ng to the experimental group feed JM No.1 decoction and JM No.1 Wenyang demolition decoction and Jinkui Shenqi pill group with corresponding drugs,configured to 10ml/d soup on the basis of the weight,then feed the Rabbits,and feed normal control group with equal distilled water.Continuing to feed high fat diet during the administrate a drug.Test index:(1)CHOL,TG,HDL-C,LDL-C(2)Ca2+(3)CDFI test the lesion in the abdominal aorta and arteria femoralis of Right posterior Lower limbs of ASO model(4)Using the lesion in the artery of ASO model to Made from pathological sectionResults: 1.The model of preparation,Normal control group compa-red with model group,The level of weight,P<0.05,the model group is obviously rise;The level of CH-OL?TG and LDL-C,P<0.05,the model group is obviously rise;The level of Ca2+ and HDL-C,P>0.05? 2.Administration:(1)model group compared with JM No.1 decoctio n group,The level of CHOL?HDL-C?LDL-C and Ca(P<0.05),the JM No.1 decoction group is obviously decrease.The level of TG(P>0.05);model group compared with JM No.1 Wen-yang demolition decoction g roup,The level of CHOL?TG?LDL-C and Ca2+(P<0.05),the JM No.1Wen-yang demolition decoction group is obviously decrease.The level of HDL-C(P>0.05);Normal control group comp-ared with Jinkui Shenqi pi ll group,The level of CHOL?TG?LDL-C and Ca2+(P<0.05),the Jinkui Shenqi pill group is obviously decrease.The level of HDL-C(P>0.05).(2)Jinkui Shenqi pill group compared with JM No.1 decoction g roup,The level of CHOL?TG?LDL-C and Ca2+(P<0.05),the JM No.1 decoction group?The level of HDL-C(P>0.05);JM No.1 decoction group compared with JM No.1 Wenyang demolition decoct-ion group,The level of TG and HDL-C(P<0.05),the JM No.1 Wenyang demolition decoction group is obviously decrease.The level of TG and LDL-C(P>0.05);Jinkui Shenqi pill group compared with JM No.1 Wenyang demolition decoction group,The level of CHOL?HDL-C?LDL-C and Ca2+(P<0.05).The level of HDL-C and TG(P>0.05)? 3.CDFI:In terms of plaque formation,JM No.1 decoction group? JM No.1 Wenyang demolition decoction group have a beneficial effect on experimental ASO.Jinkui Shenqi pill group have a poor effect on experimental ASO 4.Pathological section:JM No.1 decoction group and JM No.1 Wenyang demolition decoction group and Jinkui Shenqi pill group have a effect on atherosclerosis plaque forming of experimental ASO.Conclusion(s):1.JM No.1 Wenyang demolition decoction?JM No.1 decoction and Jinkui Shenqi pill group has obvious improvement action to the related index of experimental ASO.2.the Ca have no obvious change in model preparation before and afte,Has the same effect compared with this previous project research of“Peripheral blood serum Ca have no obvious change”.3.Through "Proof by Contradiction",Preliminary validation:this experimental model may be yang deficiency syndrome of ASO model.