Level Change And Clinical Significance Of Serum BDNF In Coronary Heart Disease Patients With Type 2 Diabetes

Objective To evaluate the Expression of brain-derived neurotrophic factor(BDNF) in scrum of patients with Coronary heart disease (CHD) with type ? diabetes(T2DM)and its clinical value.Methods 240 patients are enrolled in our research, who are admitted in the department of Cardiology of the Zhongda Hospital Affiliated to Southeast University from August 2013 to August 2015. According to medical history and the results of Coronary Angiograph(CAG), the patients are divided into 3 groups as follows:normal control group(Con):N=83; (2) CHD group:N=85; (3) CHD combined T2DM(CHD+T2DM):N=72. The concentration of serum BDNF are checked by using enzyme-linked immunosorbent assay (ELISA), the severity of coronary artery lesion is evaluated according to the Gensini score.Results1. The level of serum BDNF is significantly higher in CHD, CHD+T2DM than in Con group (p<0.01), and serum BDNF level of CHD+T2DM is significantly higher than CHD group (p<0.01)?2. Pearson correlation analysis shows that the level of BDNF is significantly correlated with gender, age, Body Mass Index (BMI), hypersensitive C-reactive protein (hs-CRP), low density lipoprotein (LDL) and glycosylated hemoglobin Ale (HbAlc) (r=0.128?r=-0.124? r=-0.175?r=0.557?r=0.021?r=-0.412, P<0.05); while smoking, hypertension, triglyceride (TG), total cholesterol(TC), high density lipoprotein (HDL) and fasting blood glucose (FBG) have no correlation with the level of BDNF (r=0.260?r=0.148?r=0.163?r=0.084?r=-0.125? r=-0.112,P>0.05).3. In the groups of CHD and CHD+T2DM, there are no significant difference in the level of serum BDNF between single and double vessel diseases, but it's significantly higher in triple vessel disease than that in single and double vessel diseases.4. CHD+T2DM group has a higher Gensini score than CHD group; The multiple linear regression analysis shows that the levels of BMI?LDL?hs-CRP and BDNF affect the Gensini score (P<0.05). The level of serum BDNF is positively correlated with Gensini score. In the group of CHD, r=0.84, P<0.01; in the group of CHD+T2DM, r-0.899, P< 0.01.Conclusions l.The serum BDNF level in the coronary artery disease patients with type 2 diabetes mellitus group is higher than that of the coronary artery disease patients without type 2 diabetes group and the normal control group; 2. The serum BDNF and Gensini scores are positively correlated, suggests that the serum BDNF level may reflect coronary artery stenosis to some extent.