| Objective: The project performs systematic observations on the efficacy and safety of antipyretic paste in the treatment of liver cancer fever.By comparing with Chaihu oral liquid,we further validate the clinical efficacy of antipyretic paste in treating liver cancer fever,and we also give its objective security evaluation.We have done preliminary clinical studies for the promotion of antipyretic paste in treating liver cancer fever,thus providing a safe and effective method for the application of traditional Chinese medicine in the treatment of liver cancer fever.Methods: All the data are from the patients(from February 2014 to February 2016)in the Department of liver,gallbladder,spleen and stomach,and the department of oncology,Kaifeng Hospital of TCM which is affiliated by Henan University of Chinese Medicine,the second hospital and the kaifeng infectious disease hospital.42 cases are randomly divided into treatment group,and the other 42 cases into the control group.Based on the conventional treatment(two groups of patients were given basic liver cancer knowledge education,reasonable diet and drug therapy prescription),the treatment group is treat with antipyretic paste on Shenque point,once a day,4 hours per time(the TCM antipyretic paste is provided by preparation room in Henan University of Chinese Medicine affiliated Kaifeng Hospital of TCM,and the pharmaceutical compositions are as follows: Radix rehmanniae,Cortex Moutan,water buffalo horn,borneol,etc.).The control group is treated with Chaihu Oral Liquid,three times a day,10 ml per time((sinopharm accurate word Z41021539),Henan Baiquan pharmaceutical company).We then observe the cooling effect of antipyretic paste on liver cancer patients regarding fever,TCM syndrome integral,card's score,adverse reactions and other related indicators of changes for further statistical analysis.Results:(1)General comparison between the two groups: By rank sum test,Statistical analysis suggests that the difference between patients in age,gender,degree of fever before treatment,TCM syndrome integral and the KPS score was not statistically significant(P > 0.05),thus the two groups have balanced comparability.(2)Antipyretic efficacy comparison: the total effective rate in the treatment groupis 92.86%,and the total effective rate in The control group is 71.43%;By rank sum test,P < 0.05,the difference is statistically significant,suggesting that both methods works,but the clinical efficacy of the treatment group is better than the control group.(3)The Chinese medicine symptom score improved significantly for patients in both groups,and there are significant differences within groups before and after treatment.After the treatment,the TCM symptom scores in two groups are significantly different(P < 0.05),and the treatment group is significantly better than the control group.(4)Comparison of patients' quality of life in two groups: By rank sum test,the treatment group and control group KPS score before and after treatment,visible KPS score were improved after treatment in both groups,including improved treatment group compared with the control group was statistically significant(P < 0.05);Two groups after treatment in patients with poor KPS score,by t test,P < 0.05,differences between the two groups was statistically significant;Shows that the two groups can improve the quality of life of liver cancer patients with fever,especially in the treatment group was better than control group in improving patients' quality of life.(5)Security Analysis: During the period of clinical observation,the treatment group and control group in both before and after treatment had no adverse reaction and the side effects,the clinical laboratory tests such as did not see changes related to drug treatment.Conclusions: 1.Traditional Chinese medicine herbal antipyretic paste can reduce fever liver cancer patients' body temperature,the overall cooling effect is significant.2Traditional Chinese medicine herbal antipyretic paste can alleviate the TCM symptom of liver cancer patients with fever and lower TCM symptom score.3.Traditional Chinese medicine herbal antipyretic paste can improve the Karnofsky score of the HCC patients,and improve their quality of life. |
PDF Full Text Request