The Preliminary Clinical Application Of Using ¹²⁵I Brachytherapy To Treat Spinal Metastases

Objective:To investigate the preliminary clinical effects of 125 I radioactive particles on patients who are suffered with spinal metastases tumors.Methods:From January 2014 to January 2016, a retrospective study was carried out in the spinal metastatic tumor patients in spine surgery of our hospital. The patients were treated with minimally invasive technique. 49 patients met the inclusion criteria which were treated by percutaneous vertebroplasty or/and percutaneous pedicle screw fixation surgery, and they were divided into experimental group(27 cases) and control group(22 cases) whether the 125 I brachytherapy was used or not. The visual analog scale(VAS) and Oswestry Disability index(ODI) scores were recorded in each group preoperation, and postoperative one day, 2 weeks, 2 months, 6 months, and 12 months. Review imaging data preoperation, and postoperative one day, 2 months. The vertebral anterior height and posterior height were recoded. To evaluate the preliminary clinical effects of 125 I radioactive particles on patients suffered from spinal metastatic tumors, the SPSS19.0 software was used for analyzing the various follow-up indicators.Results: Surgeries of all patients were performed successfully. The spinal nerve compression symptoms did not appear. The numbers of implanting 125 I radioactive particles for the experimental group in centrum are 11.95±2.91. Bone cement injected dose 2.34±0.87 ml. One case in the control group appeared re-vertebral fracture during the follow-up. One case appeared new vertebral fracture. Comparison with preoperation, the VAS score, ODI score, vertebral height of anterior column, vertebral height of posterior column, the differences were statistically significant(P <0.05). After 2 weeks, 2 months, 6 months, 12 months of follow-up postoperation, the experimental group and control group VAS, ODI were statistically significant(P <0.05). Experimental group after 2 weeks, 2 months, 6 months, 12 months after surgery, compared with 1 day postoperation, the VAS and ODI were statistically significant(P <0.05). In the control group, 2 weeks, 2 months, 6 months, 12 months postoperation compared with 1 day postoperation, the VAS and ODI were no significant difference(P> 0.05). In the two groups of patients, the vertebral height of anterior column and posterior column were not statistically significant(P> 0.05) at 2 months and 1 day postoperation.Conclusions: The two therapeutic methods that combine or not combine 125 I radioactive particles are both efficient for relieving the pain symptom of patients with spinal metastatic tumors and improving their quality of life. However, 125 I radioactive particles implantation is more beneficial to relieve their pain symptom and improve their quality of life.