| Objective:Approach to the study of this topic by using standard contrast with randomized, parallel controlled clinical trial design, Rouganxifeng soup hypothesis system to study the essence of liver Yang the efficacy and safety of the patients with migraine preventive treatment, and through the Rouganxifeng soup and the known effective migraine preventative treatment the curative effect of Flunarizine Hydrochloride Capsules contrast, further verify the Rouganxifeng Soup of partial head pain of liver Yang syndrone headache card preventive treatment clinical curative effect, and make objective evaluation on its safety.For liver extinguish wind soup in treating migraine preventative promotion makes a preliminary clinical study, for traditional Chinese medicine in treating migraine preventative use to provide a safe and effective method.Methods:Approach to the study of this topic by using standard contrast with randomized, parallel controlled clinical trial design to observe 120 cases of encephalopathy in Kaifeng City Hospital clinics of liver Yang syndrone migraine headache syndrome patients. Using SPSS software to generate random Numbers and codes, press 1:1 set the proportion of the control group and experimental group, treatment group of 60 cases, control group 60 cases, experimental group and control group therapy for 8 weeks, follow-up 4 weeks after treatment. Treatment group given internal Rouganxifeng soup, daily 1 agent, 200-300 ml water with a blunt,2 times a day;Control group given oral flunarizine hydrochloride capsules, and main ingredients:flunarizine hydrochloride,1 times 10 mg once daily. Based on patients with headache diary, observe and record in detail four weeks before the start of treatment and treatment within 4 weeks after the end of the headache, headache days, pain score, with headache symptoms and headaches affect determination-6 points, and according to the number of headache;Treat headache within 4 weeks after the end of the time;Digital measurement headache pain scale level of average score;Headache symptom integral and HIT-6 scores to determine efficacy.Results:After about 4 weeks after treatment in patients with migraine headache, headache total time, Numbers, the degree of headache pain scale measurement mean score, headache and HIT-6 score statistics analysis, the results show that the proposed Rouganxifeng Soupcan significantly reduce migraine patients with liver Yang syndrone type of headache frequency, reduce the degree of headache duration, relieve headache, improve patients with symptoms of headache attack, relieve headaches the negative effect on the patients' life. In migraine treatment, treatment group total effective rate was 90.00%, control group total effective rate was 65.00%, the difference between the two groups have statistical significance (P=0.01<0.05), the Rouganxifeng Souppreventive treatment in patients with liver Yang type syndrone migraine therapy effect is better than the control group of drug efficacy.4 weeks after treatment duration of headache, headache, determination of symptom integral and the HIT-6 points, the difference between experimental group and control group with statistical significan (P=0.01<0.05; P=0.00<0.05;P=0.00<0.00),explainexperimental drugs in reducing headache duration, reduce the degree of headache in patients with migraine headache, lower in patients with migraine headache symptom score, relieve headaches for the negative effects of life in patients with the treatment effect is better than the control group of drugs.In terms of number of 4 weeks after treatment of headache, no statistically significant difference between experimental group and control group (P=0.10> 0.05), shows that in terms of improvement in patients with migraine headache frequency, treatment group at the same therapeutic effect of drugs and the control group.In the process of treatment group and control group had no adverse reactions and the occurrence of adverse events, security in experimental group and control group in the treatment process.Conclusion:Rouganxifeng Soupcan significantly improve liver Yang syndrone the signs and symptoms of patients with migraine, is a kind of safe and effective formulas can be used for preventive treatment of migraine. |
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