A Clinical Observation To Evaluate The Efficacy Of Treating Fullness Disease(Functional Dyspepsia) With Different Types Of Invigorating Spleen Decoction Of Traditional Chinese Medicine

Purpose To observe the clinical effect of different types of Invigorating Spleen Decoction of Traditional Chinese Medicine in the treatment of Functional Dyspepsia, which was compared with placebo, then to evaluate objectively the clinical effects of traditional Chinese medicine preparation in the treatment of Functional Dyspepsia. At the same time measuring the content in plasma ghrelin(CCK, Ghrelin)to explore the mechanism of different types of Invigorating Spleen Decoction of Traditional Chinese Medicine in the treatment of Functional Dyspepsia.Method The 72 patients with Functional Dyspepsia,according to the inclusion criteria of Functional Dyspepsia,which were all from the outpatient service and sickroom of the Wuhan NO.1 hospita1 Gastroenterology from January 2014 to January 2016. In accordance with the principle of randomized and double-blind into two groups,including experimental group(45 cases)?and control group(22 cases)?Each participant must accept a routine security inspection before and after treatment,including blood, urine and dung routine inspection[+OB],liver function, kidney function, ECG and the measuring of the content in plasma ghrelin(CCK, Ghrelin). Each participant must be presented within 6 months of gastroscopy examination results sheet before treatment, no complete gastroscopy examination.Experimental group according to the fullness of spleen deficiency and qi stagnation syndrome, spleen deficiency and dampness,spleen yang deficiency were treated with the number one,two,three of spleen deficiency,while the control group received a placebo corresponding. The course of the two groups was both 4 week.At the end of the study,according to the statistical results of The postprandial distress severity point,SF-36 Quality of Life Scale,Hospital Anxiety and Depression Scale,Integral of traditional chinese medicine to evaluate the effect of different types of Invigorating Spleen Decoction of TCM.Through measuring the content in plasma ghrelin(CCK, Ghrelin)to explore the pathogenesis of functional dyspepsia and the mechanism of different types of Invigorating Spleen Decoction of TCM in the treatment of Functional Dyspepsia.Results 1?Comparison of overall efficacy in patients: The total effective rate of the experimental group is 82.22%,the control Group is 54.55%.There is statistical significance in difference of overall curative effect between experimental group and control group(P<0.01).2?Comparison of postprandial distress severity scores before and after the treatment:comprared with before treatment,there are significant differences in scores of expremental group in postprandial distress severity( P <0.01).After the treatment,threr are significant differences in scores between the expremental group and control group(P<0.01).3? Comparison of eight dimensions integration of SF-36 scale before and after the treatment:The eight dimensions integration between the two groups was no significant difference before treatment(P>0.05).Patients in the expremental group after treatment,scores of Role-Physical(RF),Role-Emotional(RE),Bodily Pain(BP),Vitality(VT),Mental Health(MH)and Social Functioning(SF) six dimensions were improved significantly(P<0.01) compared with before treatment,and better than the control group.4?Comparison of HAD scale integration before and after the treatment:Before the treatment,there were no statistical significance in the scores of anxiety and depression between the two groups(P >0.05).After the treatment,scores of the experimental group patients with anxiety were decreased compared with before treatment,the difference was statistically significant(P < 0.01),but the reduction of depression score was no significany(P >0.05).Compared with the control group,the depression integration was no significant difference between the two groups(P >0.05),while the change of anxiety score was statistical significance(P<0.01).5?Comparisom of the contents of CCK,Ghrelin before and after the treatment:Before the treatment,there were no significance in the contents of CCK,Ghrelin(P >0.05,P >0.05).The contents of CCK were decreasing after the treatment in experimental group.There are significance in the contents of CCK between after the treatment and before the treatment in experimental group(P <0.05).There are significance in the contents of CCK between the experimental group and the control group after the treatment(P <0.05).while the Ghrelin were increasing after the treatment in experimental group.There are significance in the contents of Ghrelin between after the treatment and before the treatment in experimental group(P <0.05).There are significance in the contents of Ghrelin between the experimental group and the control group after the treatment(P <0.05).Conclusions This study shows that the different types of Invigorating Spleen Decoction of Tranditional Chinese Medicine for the patients with FD have a certain therapeutic effect.The overall curative effect of experimental group has been better than control group.After the treatment the patients of the experimental group which postprandial distress severity have obviously improved,better than the control group.After the treatment,the RF,RE,BP,VT,MH,SF of the experimental group was obviously improved,better than the control group.The improvement of anxiety was obvious in the patients of experimental group after the treatment,better than the control group.Compared with before treatment,The contonts of CCK were obviously decreased and Ghrelin were obviously increased in exprimental group.