Research Of The Occurrence Factors Of Common Gastrointestinal Tumor-related Depression, Anxiety

Objective:WHO announced cancer is a chronic disease officially in 2006,different diseases,different stages bring different effects for different patient and families,which show different levels of depression,anxiety.Esophageal cancer,gastric cancer,colorectal cancer is the common digestive tract tumor in our country,they are caused by the chronic inflammation and ulcer,which are result from eating habits,personal health and mental psychological factors.The morbidity and mortality of the cancer rises gradually in recent years.The comprehensive treatment model of common digestive tract tumor includes surgery,systemic chemotherapy,radiation therapy,targeted therapy,traditional Chinese medicine treatment,etc.Most of the patients experienced a variety of treatments,the body had left a scar and/or a fistula that is different with physiological anatomy.In the process of the treatment,the adverse brings patients physical,psychological,spiritual and social symptoms,such as fatigue,anxiety,depression,sleep disorders,autonomic nerve dysfunction,etc.These symptoms tend to appear at the same time,which has the serious influence in the patients' quality of life.This study will probe into the overall morbidity of cancer-related depression,anxiety and the related risk factors of the diseases by collecting clinical data,analyzing psychological questionnaire in patients with common digestive tract tumor of three general hospitals of Shijiazhuang.Method:1 Collect 300 cases of common digestive tract tumor patients who were treated in 3 major tumor hospitals of Shijiazhuang(Fourth Hospital of Hebei Medical University,Second Hospital of Hebei Medical University,Hebei University Affiliated Hospital)from 2015-02 to 2015-12.They were diagnosed common gastrointestinal tumor by pathological and radiological examination.2 We collect the patients' disease information and demographic data.In order to evaluate the overall morbidity of cancer-related depression,anxiety and the related risk factors of the diseases,the study requires all the demographic data completed the following questionnaires themselves: SAS,SDS.3 Statistical analysis: the study uses SPSS21.0 software to describe the demographic characteristics of all the subjects.There are 9 variables that were selected,such as gender,age,the economic burden,the degree of knowledge,etc.Use the four table chi-square test to analyze the factors and the relationship between factors and cancer-related depression and anxiety.Use Logistic regression analysis to analyze the risk factors.Inspection level ? =0.05,the meaning of P <0.05 is Statistically significant,P >0.05 is of no significant difference.Results: 1 The overall morbidity of common gastrointestinal tumor-related depression and anxietyIn 300 cases of effective analysis data,there are 252 valid questionnaires,and 48 patients lost to follow-up.The morbidity tumor-related of depression is 40.4%,the morbidity of tumor-related anxiety is 30.7%,and the morbidity of depression associated with anxiety is 21.0%.1.1 The overall morbidity of common Upper Gastrointestinal Tract-related depression and anxietyWe take back 147 questionnaires,which include 126 complete and effective questionnaire.In 126 cases of effective analysis data,the male patients 99 cases(78.5%),the female patients 27 cases(21.4%),the median age was 61(28-84 years old).The morbidity tumor-related of depression is 44.4%,the morbidity of tumor-related anxiety is 30.2%,and the morbidity of depression associated with anxiety is 21.4%.1.2 The overall morbidity of colorectal cancer-related depression and anxietyWe take back 153 questionnaires,which include 126 complete and effective questionnaire.In 126 cases of effective analysis data,the male patients 64cases(50.8%),the female patients 62 cases(49.2%),the median age was 58(23-81 years old).The morbidity tumor-related of depression is 36.5%,the morbidity of tumor-related anxiety is 31.0%,and the morbidity of depression associated with anxiety is 20.6%.1.3 The differences of the morbidity of cancer-related depression and anxiety between colorectal cancer and esophageal cancer,stomach cancerThere is no significant difference the morbidity of cancer-related anxiety(31.0% vs 30.2%),but the incidence of colorectal cancer-related depression is more lower than esophageal cancer and stomach cancer'(36.5% vs 44.4%)2 The factors of common gastrointestinal tumor-related depression and anxiety 2.1 The factors of gastric cancer and esophageal cancer-related depression and anxietyAnalyze gender,age,residence,the stage of the disease,distant metastases,the degree of education,the economic burden,the degree of disease knowledge,dosing intervals as 9 grouping variables.The result show that gender,the economic burden and the degree of disease knowledge have highly significant influence on the morbidity of cancer-related anxiety(P<0.05);and the gender,the economic burden,the degree of disease knowledge,distant metastases,and the degree of education have highly significant influence on the morbidity of cancer-related depression(P<0.05);the age,residence and dosing intervals have no significant influence on the morbidity of cancer-related anxiety and depression(P > 0.05).The situation of distant metastases is the independent risk factors for the onset of depression(P = 0.004);the morbidity of cancer-related anxiety has no independent risk factors.2.2 The factors of colorectal cancer-related depression and anxietySimilarly,there are 9 grouping variables.The result show that the gender,the economic burden,the degree of disease knowledge,the stage of the disease,distant metastases,and the degree of education have highly significant influence on the morbidity of cancer-related depression(P<0.05);and the gender,the degree of disease knowledge,the stage of the disease,distant metastases have highly significant influence on the morbidity of cancer-related anxiety(P<0.05);the age,residence and dosing intervals have no significant influence on the morbidity of cancer-related anxiety and depression(P > 0.05).The gender and the degree of disease knowledge is the independent risk factors for the onset of anxiety(P = 0.004);the independent risk factor of the morbidity of cancer-related depression is education level.Conclusion:1 Patients with digestive tract tumor have a high degree of cancer-related anxiety and depression that concentrates in mild and moderate anxiety and depression,which is same with the foreign studies.2 Compared with the onset of the common gastrointestinal tumor-related anxiety,there are more tumor-related factors that affect the onset of depression.3 Gender,the degree of knowledge,the economic burden have an influence on the occurrence of esophageal/ gastric cancer-related anxiety and depression;the situation of distant metastases is an independent risk factors of esophageal/gastric cancer-related depression.4 Gender,the disease stage,the degree of disease knowledge have an influence on the occurrence of Colorectal cancer-related anxiety and depression;the degree of education is an independent risk factors of Colorectal cancer-related depression;the independent risk factors of the occurrence of anxiety are the degree of disease knowledge and gender.