Clinical Observation Of Escitalopram Combined With Bailemian Capsule Treatment To Chronic Insomnia With Anxiety And Depression

Objective: To investigate the therapeutic effect of escitalopram combined with Bailemian Capsule on insomnia with anxiety and depression.Methods: 100 patients with chronic insomnia were enrolled in sleep disorders clinic of the First Hospital of Hebei Medical University from June 2013 to June 2015,according to the ICD-10 diagnosis of insomnia.Hamilton Depression Scale 24-item version(HAMD₂₄)and Hamilton Anxiety Scale 14-item version(HAMA₁₄)were used to evaluate the anxiety and depression of patients.Patients were randomly divided into control group and combined treatment group,there were 50 cases in each group.The control group patients were treated with escitalopram,combined treatment groups were treated with escitalopram combined with Bailemian capsule for 8 weeks.All patients took eszopiclone to treat insomnia when they needed.The anxiety,depression mood and sleep quality of patients were evaluated by HAMD₂₄,HAMA₁₄ and Pittsburgh sleep quality index?PSQI?before and after 2 week and 8 week treatment.The reduction rate of HAMD₂₄,HAMA₁₄ and PSQI were compared between the two groups.The incidence of adverse reaction was recorded.The efficacy on sleep quality,anxiety and depression emotion and adverse reactions of patients in two groups were compared between two groups.Results:1The general information of the two groups100 cases were enrolled,there were 36 male and 64 female.Age was from 32 to 84 years,mean age was between 48.5±6.9 years.The mean duration was 8.0±1.2 months.All patients were randomly divided into two groups.There were 50 cases in the combined group,19 male,31 female,mean age was between 56.0±6.2 years,The mean course was 8.5±1.5 months.There were 50 cases in the control group,17 male,33 female,mean age was between 60.0 ±1.7 years.The mean duration was 7.5±1.3 months.There were no difference in age,sex,duration,PSQI scores,HAMA₁₄ scores?HAMD₂₄ scores before treatment in both groups?P>0.05??2 The comparison of sleep quality improvement in two groupsThe PSQI scores of combined treatment group were statistically higher less those of control group after 2 week and 8 week treatment?P < 0.05?.The total effective rate of sleep quality was significantly statistically higher than that of the control group after 8 week treatment?P < 0.05?.Drug withdrawal rate of eszopiclone in the combined treatment group was statistically higher than that of the control group?P < 0.05?.3 The comparison of anxiety improvement in two groupsAfter 2 week treatment,HAMA₁₄ scores of the control group was lower than that of before treatment,while there was no significantly difference?P>0.05?,HAMA₁₄ scores of the combined group was significantly lower than that of before treatment?P<0.05?.HAMA₁₄ scores of the combined treatment group was significantly lower than that of control group after 2 week treatment?P<0.05?.Compared with before treatment,HAMA₁₄ scores were significantly lower in both groups after 8 week treatment?P<0.05?,while there was no difference between control group and combined treatment group?P>0.05??The total effective rate of anxiety was significantly statistically higher than that of the control group after 8 week treatment?P < 0.05?.4 The comparison of depression improvement in two groupsAfter 2 week treatment,the control group and the combined treatment group of patients with HAMD₂₄ scores were lower than before treatment,the difference was statistically significant?P < 0.05?;and the two group HAMD₂₄ score comparison,the difference was not statistically significant?P > 0.05?.After 8 weeks of treatment,the two groups of patients with HAMD₂₄ scores were lower than before treatment,the difference was statistically significant?P < 0.05?;and the combined treatment group HAMD₂₄ score was lower than the control group,the difference was statistically significant?P < 0.05?.The total effective rate of the treatment group was significantly higher than that of the control group,the difference was statistically significant?P < 0.05?.5 The comparison of adverse reactions in two groupsThe incidence of nausea,headache,dizziness,sweating in the combined treatment group was significantly less than that of the control group?P < 0.05?.The incidence of dry mouth,bitter mouth,constipation in the combined treatment group was lower than the control group?P < 0.05?.The total incidence of adverse reactions in the combined treatment group was lower than that of the control group?P < 0.05?.There was no abnormality in blood routine,liver function of patients before and after treatment in both groups.Conclusions: Escitalopram combined with Bailemian capsule has good effect in the treatment of insomnia with anxiety and depression effect,the improvement of insomnia,anxiety and depression symptoms was better than escitalopram treatment.Bailemian capsule help to discontinue using sedative hypnotics and could effectively reduce adverse reactions such as nausea,dizziness,headache,sweating,dry mouth,bitter mouth,constipation.