| Objective: This research is by observing the Huangxiong Kangshuan Capsules,intervention in patients with carotid atherosclerotic vulnerable plaque changes after the relevant indicators, mainly is the carotid intima-media thickness, the change of serum inflammatory index, lipid levels, and combining with TCM syndrome score changes of the patients before and after treatment, to evaluate Huangxiong Kangshuan Capsules on the curative effect of vulnerable plaques, and to explore the possible mechanism.Methods:(1) Objects were from the first affiliated hospital of anhui medical university encephalopathy center from January 2015 to December 2015 outpatient service and a total of 70 cases of hospitalized patients, all through the pa/screening criteria for the diagnosis of vulnerable plaques.(2) The exclusion criteria: The acute phase of cerebral apoplexy patients, and recently has serious injured or accept the heavy hand performer, pregnancy or lactation women,patients with organ failure and so on.3) Use the block randomized grouping method, 70 patients(43 cases in men and 27women), were randomly divided into treatment group(n = 35), the control group(n =35). Two groups of age, gender, and merge disease(high blood pressure, diabetes,coronary heart disease) there was no significant difference by statistical tests, and sign the informed consent.(4) The treatment group and control group patients were to be foundation treatment with oral aspirin enteric-coated metformin hydrochloride 100 mg, 1 times a day(bayer healthcare), 20 mg of atorvastatin calcium tablet, 1 times a day(Pfizer pharmaceutical co., LTD.). Treatment group on the basis of conventional treatment combined with 800 mg Huangxiong Kangshuan Capsules, 3 times/day(the first affiliated hospital of Anhui University of Chinese Medicine hospital preparation approval number: anhui words Z20080012 medicine system). Observe the carotid intima-media thickness(IMT), lipid levels, serum inflammatory indexes and the change of TCM syndrome integral of two groups after treatment of 90 d, comparison and statistics. The treatment of each group is not added with similar or other lipid regulating drugs, and according to the condition needs to be anti hypertension and hypoglycemic treatment. Before and after medication, the comparison of data within a paired sample t test, index difference between group compared with two independent sample t-test, Ridit analysis level data. Results: P take on both sides, when P < 0.05,there are significant differences in statistics; When P < 0.01, has the extremely significant difference in statistics; When P > 0.05, said no difference in statistics.Results:(1) The carotid intima-media thickness(IMT):The IMT of treatment group before treatment was 3.01±0.85 mm, after treatment was 1.69±0.48 mm, the IMT of control group before treatment was 3.03±0.84 mm, after treatment was 2.47±0.67 mm,therapy in the first two groups of carotid IMT contrast P > 0.05, there was no statistical difference. In the two groups after treatment of carotid IMT contrast group P < 0.05, were statistically significant differences. Carotid IMT contrast between treatment group and control group P < 0.05, there are statistically significant differences.(2) Lipid levels: TC?TG?LDL?HDL of the two groups before treatment there were no statistical differences(P > 0.05). Lipid levels after treatment in two way contrast there are statistically significant differences(P < 0.05). Comparison between groups,TC no statistical difference(P > 0.05). The rest of the index contrast have statistically significant difference(P < 0.05).(3) C-reactive protein(CRP) : The CRP of treatment group before treatment was6.91±0.97 mg/L, and the control group before treatment was 6.89±0.96 mg/L. The CRP of treatment group after treatment was 4.97±1.19 mg/L, the control group was6.09 ±1.17 mg/L. There were no statistically significant differences in the two groups(P>0.05). After treatment, there were significant differences in the two groups(P<0.05). There was a significant difference between the groups(P<0.05).(4)TCM syndrome integral: TCM syndrome integral of two groups before treatment there were no statistical differences(P>0.05),after treatment, there were significant statistical differences in the two groups(P<0.05), there were significant differences between the groups(P<0.05).Conclusion:(1)The huangxiong kangshuan capsule can effectively improve carotid atherosclerosis,reduce plaque volume;(2)The huangxiong kangshuan capsule can significantly decrease the serum level of CRP, has good anti-inflammatory effect;(3)Third huangxiong kangshuan capsule can be excellent lipid-lowering lipid regulating effect;(4)The huangxiong kangshuan capsule in improving TCM symptoms integral effect due to the pure western medicine treatment group;(5)The effect of antiplatelet drugs and statins in stable plaque is worthwhile... |
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