Different Time Of Different Electroacupuncture Scalps Point-through-point Therapy On Activity Of Substantia Nigra Including Ca²⁺-ATPase In The Brain Of Rat With Parkinson's Disease

Objective:By studying the electric needle acupuncture point through stab at different time points(14 d 28) Parkinson's disease model in rats nigra Ca2 +- ATPase activity impact experiments, discusses electric needle acupuncture point through thorn in the treatment of Parkinson's disease calcium maintain stability in the process of cellular and molecular mechanisms. Methods:(1) the 6- hydroxy dopamine(6- OHDA) striatum double targets injections copy Parkinson's disease model in rats, through the(APO) on morphine induced behavioral detection and TH immune histochemical method validation model of success.(2) set up including music group, the pulse electric acupuncture group, beauty ba group, model group, control group, the blank group.(3) between groups in treatment for 14 days, 28 days respectively, using spectrophotometry in the substantia nigra in rats Ca2 +- ATPase activity, detection of Parkinson's disease model rats before and after building the changes of enzyme activity. The data analysis are applied in the study of SPSS18.0 statistical software. Results:Compared with the blank group, Madopar group rat brain in substantia nigra of Ca2+-ATPase activity significantly reduced(P < 0.01), pulse EA group rat brain substantia nigra of Ca2+- ATPase activity compared with the blank group, the content of slightly decreased(P < 0.05), the music electroacupuncture group rat brain substantia nigra of Ca2+-ATPase activity compared with the blank group, the content of numerical no significant change(P > 0.05). Compared with the model group, the substantia nigra Ca2+-ATPase activity in brain of rats with Madopar group had no significant change(P>0.05). Compared with Madopar group, pulse EA group, the substantia nigra Ca2+-ATPase activity in brain of rats with EA group increased significantly(P<0.05). Compared with pulsed electro acupuncture group, EA group rat brain substantia nigra Ca2+-ATPase activity increased significantly(P<0.05). Conclusion:1 electroacupuncture scalp acupuncture point through the thorn Parkinson model rat brain substantia nigra Ca2+-ATPase activity has a regulatory role. Without the influence of Western medicine Madopar substantia nigra Ca2+-ATPase activity on the Parkinson model in the rat brain.2 the effect of electroacupuncture scalp acupuncture on the activity of substantia nigra Ca2+-ATPase in the brain of Parkinson model rats was related to the treatment cycle, and the influence was weakened after the treatment reached a certain period.3 the effect of the electro acupuncture for the music electro acupuncture is more superior to the curative effect of the treatment of Parkinson disease.